Passion Struck with John R. Miles

How to Change Your Brain's Destiny Before It's Too Late | Dr. David Perlmutter – EP 809

August 20, 2026·1h 1m·5-min readnarrativehealth
Podzilla Summary (5 min)
TLDR
The brain's immune cells, called microglia, can either protect or damage brain health depending on lifestyle choices, and Dr. David Perlmutter argues that metabolic health is the key factor determining whether these cells act as defenders or destroyers. This episode reframes brain disease

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Guest

D

Dr. David Perlmutter

narrative on Passion Struck with John R. Miles

Mentions

Books, people, and resources mentioned in this episode.

People

Dr. David PerlmutterJohn R. MilesRudolph TanziDean Ornish

Books

Brain Defendersby Dr. David Perlmutter

Companies

drperlmutter.com

Products & Tools

GLP-1 agonistsTSPO PET scan

Research & Papers

Cochrane analysis

Topics

BiohackingGut HealthLongevityMental HealthNeuroscienceNutritionSleep

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