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by Nick Jikomes
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- 4 days ago1h 1m
Pregnenolone & Corticosteroids in the Brain | Sherwood Brown | Episode 293
Send us Fan Mail Pregnenolone, a neurosteroid derived from cholesterol, affects brain activity and shows promise for treating mood and substance abuse disorders. TOPICS DISCUSSED: Steroid Biosynthesis: Cholesterol converted to pregnenolone, the precursor for all steroid hormones including cortisol, aldosterone, and sex hormones.Corticosteroids: Synthetic versions like prednisone primarily target glucocorticoid receptors for anti-inflammatory uses but can impact mood and cognition.Pregnenolone...
- 1 weeks ago1h 46m
Omega Fats & ω-3 Supplements in Human Health | Bill Harris | Episode 292
Send us Fan Mail How omega-3 fats in human health, including dietary intake needs, supplements, & omega fat testing. TOPICS DISCUSSED: ω-3 chemistry: EPA and DHA differ from plant ALA in chain length and double-bond count, making them structurally and biologically distinct — and largely irreplaceable by ALA conversion.ALA-to-EPA/DHA conversion: A small percentage of dietary ALA converts to EPA, and conversion to DHA is even lower; vegans rely on this inefficient pathway for all long-chain...
- 2 weeks ago1h 55m
Omega Polyunsaturated Fats in Inflammation | Philip Calder | Episode 291
Send us Fan Mail How dietary fatty acids regulate the initiation, propagation, and resolution of inflammation. TOPICS DISCUSSED: Parenteral nutrition history: IV nutrition evolved from soybean oil alone in the 1960s to complex blends including fish oil as the biology of ω-3s became understood.Three phases of inflammation: Initiation, propagation (driven by ω-6–derived prostaglandins and leukotrienes), and active resolution (driven by ω-3-derived resolvins and protectins).Pro-resolving mediato...
- 3 weeks ago1h 24m
Reversing Alzheimer's & Neurodegeneration: Latest Science | Andrew Pieper | Episode 290
Send us Fan Mail A metabolic view of Alzheimer's disease & the recent discovery of compounds that reverse advanced disease symptoms in mouse models by restoring mitochondrial health. TOPICS DISCUSSED: Classic Alzheimer’s pathology: amyloid plaques and tau tangles identified over 120 years ago, long assumed to drive irreversible neuron loss.Limitations of amyloid focus: plaques appear in some cognitively normal brains; antibody therapies have shown limited clinical benefit.Metabolic perspe...
- Apr 17, 202650 min
How Parental Exercise Effects Offspring Health | Kristin Stanford | Episode 289
Send us Fan Mail How exercise in parents can improve the metabolic and cardiovascular health of their offspring through epigenetic mechanisms. TOPICS DISCUSSED: Parental exercise & offspring metabolic health: exercise before and during pregnancy improves glucose tolerance and reduces fat gain in offspring.Paternal effects via sperm: moderate voluntary wheel running alters small non-coding RNAs, especially tRNA fragments, in sperm and enhances glucose clearance, with stronger benefits in f...
- Apr 10, 20261h 59m
Vagus Nerve Stimulation & Inflammation | Kevin Tracey | Episode 288
Send us Fan Mail How the vagus nerve regulates inflammation; bioelectronic therapies to treat inflammatory conditions. Nick speaks with Dr. Kevin Tracey about inflammation as a major driver of modern diseases, the vagus nerve’s role in balancing immune responses via reflexes, limitations of anti-cytokine drugs, and emerging bioelectronic medicine using targeted nerve stimulation. TOPICS DISCUSSED: Inflammation is related to diseases that contribute to most deaths today: heart disease, diabete...
- Apr 3, 20261h 50m
Light, Hunger & Mitochondria: Non-Image Forming Effects of Sunlight | Alexis Cowan | Episode 287
Send us Fan Mail How light regulate circadian rhythms, mitochondrial function, hormones, and appetite. Nick & Dr. Alexis Cowan discuss non-image-forming effects of light on the body, from melanopsin-driven circadian signaling in the eye to UV-stimulated pathways in skin and brain that influence melatonin, cortisol, melanin production, and energy balance. TOPICS DISCUSSED: Melanopsin & non-image-forming light: blue light signals daytime to the SCN master clock, suppressing melatonin an...
- Mar 29, 20261h 9m
Sleep, Brain Fat & Oxidative Stress | Amita Sehgal | Episode 286
Send us Fan Mail Is the fundamental purpose of sleep to remove oxidized fats from the brain? Nick & Dr. Amita Sehgal talk about the latest science on why animals sleep. Using fruit flies, her lab shows that waking generates oxidized lipids in neurons that are shuttled to glia and then cleared by macrophage-like cells during sleep. This process protects mitochondria, supports memory, and links sleep to metabolic cleanup rather than just rest. TOPICS DISCUSSED: Drosophila as a model: Fruit ...
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About Mind & Matter
Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.Not medical advice.At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking
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