Mind & Matter

Sleep, Brain Fat & Oxidative Stress | Amita Sehgal | Episode 286

March 29, 2026·1h 9m
Episode Description from the Publisher

Send us Fan Mail Is the fundamental purpose of sleep to remove oxidized fats from the brain? Nick & Dr. Amita Sehgal talk about the latest science on why animals sleep. Using fruit flies, her lab shows that waking generates oxidized lipids in neurons that are shuttled to glia and then cleared by macrophage-like cells during sleep. This process protects mitochondria, supports memory, and links sleep to metabolic cleanup rather than just rest. TOPICS DISCUSSED: Drosophila as a model: Fruit ...

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