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by Karen Toffler Charitable Trust
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- 6 days ago45 min
The Hidden Genome: How Mitochondrial DNA Shapes Aging and Disease
The Hidden Genome Inside Every Cell Most of us learned that mitochondria are the “powerhouse of the cell.” What we didn’t learn? They carry their own DNA — and that DNA may hold crucial answers to aging, neurodegeneration, and rare childhood diseases. In this episode of Research Renaissance, host Deborah Westphal speaks with Dr. Stefan Isaac, Assistant Professor at Boston University and 2025 Toffler Scholar, about how mitochondrial DNA is organized, regulated, and why its dysfunction may...
- 1 weeks ago46 min
Rewiring Mental Health: Nature-Inspired Brain Medicine with Dr. Jacob Hooker
What if the next breakthrough in mental health didn’t start in a lab — but in nature? In this episode of Research Renaissance, host Deborah Westphal speaks with Dr. Jacob Hooker, neuroscientist, entrepreneur, and CEO of Sensorium Therapeutics. Dr. Hooker shares how his journey from textile chemistry to molecular imaging led him to build a biotech company focused on nature-inspired treatments for anxiety and other neurological conditions. With nearly 20% of the U.S. population diagnosed with a...
- 2 weeks ago49 min
Rethinking Depression: Why Mental Health Is a Whole-Body Disease
What if depression and anxiety are not just disorders of the brain, but conditions shaped by the entire body? In this episode of Research Renaissance, host Deborah Westphal speaks with Dr. Scott Russo, Director of the Brain Body Research Institute at Mount Sinai, about a major shift underway in mental health science. His work challenges the long-standing brain-only model of psychiatric illness and explores how inflammation, immune signaling, and organ systems interact with the brain to shape ...
- 3 weeks ago59 min
Bioethics at the Bedside and Beyond: How Ethics Shaped Modern Medicine
Modern medicine is not shaped by science alone. It is shaped by ethics, trust, and the difficult decisions made when technology moves faster than society can understand it. In this episode of Research Renaissance, legendary bioethicist Dr. Art Caplan reflects on a career that helped build the field of bioethics from the ground up. From surviving polio as a child to shaping national policies on organ transplantation, informed consent, and end-of-life care, Caplan offers a deeply personal and h...
- Apr 15, 202658 min
Can We Halt Parkinson’s Progression? Targeted Brain Therapies Explained
Parkinson’s disease begins decades before symptoms appear — and by the time tremors start, brain changes have already been unfolding for years. In this episode of Research Renaissance, host Deborah Westphal speaks with Dr. Zachary Sorrentino, neurosurgeon, physician-scientist, and 2025 Toffler Scholar at the University of Florida. Dr. Sorrentino explains how misfolded proteins like alpha-synuclein spread through the brain, how deep brain stimulation helps restore movement, and why preve...
- Apr 8, 202654 min
Is Parkinson’s a Whole-Body Disease? Rethinking the Immune System’s Role
For decades, Parkinson’s disease has been viewed primarily as a disorder of dopamine-producing brain cells. But what if that’s only part of the story? In this episode of Research Renaissance, host Deborah Westphal sits down with Dr. Rebecca Wallings, Assistant Professor of Neurology at Indiana University’s Stark Neuroscience Research Institute, to explore a groundbreaking shift in how we understand Parkinson’s. Dr. Wallings explains why the immune system — and specifically immune cell exhaust...
- Apr 1, 202651 min
How MicroRNAs Could Change Early Detection of Alzheimer’s Disease
In this episode of Research Renaissance, host Deborah Westphal sits down with neuroscientist Micaelly Alves, PhD candidate at Temple University and a 2025 Toffler Scholar supported by the Karen Toffler Charitable Trust. Micaelly shares her personal journey into neuroscience, inspired by watching her grandmother’s battle with Alzheimer’s disease, and dives into groundbreaking research on microRNAs, tiny molecules that may hold the key to earlier diagnosis and more personalized treatment for Al...
- Mar 25, 202656 min
From Neuroscience to State Policy: How Science Shapes Decisions in California
How does neuroscience shape state policy? And what happens when scientists step inside government? In this episode of Research Renaissance, Deborah Westphal sits down with Dr. Julianne McCall, CEO of the California Council on Science and Technology (CCST), to explore how scientific thinking informs public policy in one of the world’s largest economies. From spinal cord injury research in Germany to advising California’s Governor during COVID-19, Dr. McCall shares how scientists can help gov...
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About Research Renaissance: Exploring the Future of Brain Science
Welcome to Research Renaissance, presented by the Karen Toffler Charitable Trust. We invite you into the stories, struggles, and breakthroughs shaping the future of human health. From cutting-edge brain science to discoveries transforming how we heal, adapt, and thrive, we explore the ideas that matter and the people behind them.Each episode features early-career researchers driven by curiosity, entrepreneurs turning bold ideas into lifesaving innovations, and leaders in investment, policy, and research who help move discoveries into the real world.Together, we look across diseases, technologies, and research fields to understand not just what is changing, but why it matters—for patients, families, and the future we all share.Join us as we uncover new insights, spark collaboration, and illuminate the science that can improve lives.
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