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The Feldman Protocol: Daily Summaries Delivered
by Dave Feldman
Dave Feldman hosts the Feldman Protocol, a long form, in-person podcast largely covering science, nutrition, and technology – with a lot of personal stories, interests and pop culture mixed in.
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The most recent episodes — sign up to get AI-powered summaries of each one.
- 3 days ago1h 51m
The Stent Myth: Why Fixing a Blockage Isn’t a Cure - Dr. Arthur Agatston
In this episode of The Feldman Protocol, how well do conventional cardiovascular risk metrics actually identify who is truly at risk for a heart attack decades before it happens? Cardiologist Arthur Agatston (MD) makes the case for coronary calcium scoring as an early detection tool, discusses the natural history of atherosclerotic plaque, revisits key moments in lipid science history, explores why stent placement in asymptomatic patients presents a more complex picture than intuition suggests, and shares observations on the evolving role of CT angiography and AI-assisted plaque analysis.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/50` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & introduction7:46 – Arthur's path into medicine18:59 – Early cardiology & clinical trials27:47 – Lipid science history & Ancel Keys39:04 – Rabbit studies & lipoprotein discovery47:15 – Ultra-fast CT arrives at Sinai55:26 – Collateral vessels & total occlusion1:00:00 – Ischemia trial: stents vs. medical therapy1:05:01 – Back to the CAC origin story1:13:09 – Soft vs. calcified plaque progression1:21:40 – FH patient with zero CAC score1:26:53 – The Agatston score is named1:33:51 – Power of zero & plaque burden1:39:35 – CAC vs. CT angiogram explained1:44:19 – Resistance to new imaging technology1:48:34 – Nutrition interest in the 1990s1:49:25 – Heart Lung AI & plaque ratio research1:51:11 – Closing reflections#FeldmanProtocol #DaveFeldman #ArthurAgatston #CoronaryCalcium #HeartHealth #Atherosclerosis #CardiacImaging #CACScore #LDL #Lipids #PlaqueBiology #CTAngiogram #CardiologyResearch #LowCarbDiet #LeanMassHyperResponder #HeartDiseasePrevention #LipidScience #CardiovascularResearch
- 1 weeks ago1h 56m
Isabella Cooper – Part 2 – Ketogenic Diet and Cancer: What the Science Actually Shows
In this episode of The Feldman Protocol, how does insulin influence cancer cell behavior — and what does that mean for metabolic approaches to the disease? Dave sits down with Isabella Cooper (PhD) to explore the glucose-ketone index and its practical limits, the role of glutamine alongside glucose in cancer metabolism, how mitochondrial dysfunction and cardiolipin loss may relate to tumor progression, the case for high-dose intravenous vitamin C, osteocyte biology and the surprising systemic roles of osteocalcin, and what makes a rigorous research culture.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/49` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & intro1:08 – Cancer metabolism overview2:24 – Glucose-ketone index explained5:01 – Lean mass hypersponders & glucose9:18 – Acetone measurement & respiration13:49 – Insulin, ketones & cancer signaling19:05 – Growth factors & VEGF discussion25:29 – Stomach acidity & nutrient absorption32:08 – How cancer cells originate35:43 – Cardiolipin, melatonin & apoptosis43:05 – Diet quality & food as function52:14 – Chemotherapy & metabolic protocols1:03:36 – Patient outcomes & biopsy risks1:14:32 – IV vitamin C trial findings1:22:07 – Ideal cancer metabolism trial design1:29:36 – Sunlight, melanin & mitochondria1:37:20 – Osteocyte biology & osteocalcin1:46:43 – Research culture & scientific rigor1:54:36 – Most underappreciated biomarker#FeldmanProtocol #DaveFeldman #IsabellaCooper #CancerMetabolism #KetogenicDiet #Mitochondria #Insulin #GlucoseKetoneIndex #Osteocalcin #IntravenousVitaminC #Ketosis #MetabolicHealth #LowCarbScience #CancerResearch #Cardiolipin #Osteocytes #BloodWork #Hyperinsulinemia #MitochondrialHealth #PodcastScience
- 1 weeks ago2h 22m
Isabella Cooper – Part 1 – The Chemical Removed From Tampons Is Still in Most Diapers
In this episode of The Feldman Protocol, what does beta-hydroxybutyrate between meals actually reveal about a person's insulin state — and why might that matter for understanding chronic disease risk? Dave sits down with Isabella Cooper (PhD), a biochemistry and pathophysiology scientist whose research spans assay quality control, hyperinsulinemia detection, ketone thresholds, mitochondrial function, and the lipid energy model, making the case that personalized insulin thresholds — not population-wide cutoffs — may be key to identifying subclinical metabolic dysfunction.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/48` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & intro1:06 – Isabella's background & credentials3:05 – East-meets-West medicine upbringing5:43 – Ballet, modeling & low-carb insights6:36 – Industrial design degree & lab thinking8:58 – Assay quality problems in undergrad lab12:08 – Coefficient of variation explained17:01 – Standardizing vortex & sample handling27:30 – Back to timeline: the 15-year gap39:52 – Pregnancy, diapers & toxicology deep dive53:06 – Old physiology papers vs modern science1:00:05 – Osteocalcin hypothesis & being wrong1:06:48 – Ben Bikman, mitochondria & insulin1:19:40 – Headwinds for low-carb research1:34:19 – Personalized insulin threshold concept1:41:28 – Beta-hydroxybutyrate as insulin surrogate1:51:44 – Leptin, IGF-1 & multi-marker detection2:09:09 – Subclinical hyperinsulinemia marker cluster2:14:20 – Fasting, lipid dynamics & VLDL traffic#FeldmanProtocol #DaveFeldman #IsabellaCooper #Hyperinsulinemia #Ketosis #Mitochondria #MetabolicHealth #InsulinResistance #BetaHydroxybutyrate #LowCarb #ChronicDisease #LipidEnergyModel #AssayQuality #KetoneThreshold #LaboratoryScience #Bioenergetics #BloodTesting #Inflammation
- 2 weeks ago3h 28m
Dr Scott Murray – Is IVUS Plaque ‘Regression’ Just Measurement Noise?
In this episode of The Feldman Protocol, how much does metabolic health shape cardiovascular risk beyond what standard lipid markers can reveal? Dave Feldman sits down with Scott Murray (MD), a UK-based interventional cardiologist, to explore plaque imaging and its limitations, the role of visceral and perivascular fat in heart disease, the lipid energy model and lean mass hyper-responders, cardiac fuel metabolism and heart failure with preserved ejection fraction, and the challenges of conducting and interpreting cardiovascular trials.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/47` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & Scott's intro14:21 – Scott's cardiology practice17:28 – Invasive vs. CT angiography24:49 – Collaterals & microvascular function34:31 – Glycocalyx & endothelial health40:28 – Perivascular fat & imaging51:14 – Imaging, CAC, and plaque noise1:00:04 – Lipid hypothesis & population context1:07:05 – CT plaque measurement variability1:19:42 – Perivascular inflammation & Caristo scoring1:29:07 – Lipid energy model discussion1:49:43 – LP(a), acute-phase markers & reverse causation2:05:01 – LMHR study timeline & next scans2:22:57 – Heart fuel preference & HFpEF2:39:08 – PCSK9 trials & all-cause mortality2:52:06 – Run-in periods & trial design concerns3:05:00 – Context, guidelines & patient conversations3:17:35 – GLP-1 peptides & obesity biology3:26:28 – Where to find Scott & closing thoughts#FeldmanProtocol #DaveFeldman #ScottMurray #PreventiveCardiology #HeartHealth #LipidHypothesis #LeanMassHyperResponder #CTAngiography #PlaqueImaging #CardiovascularResearch #MetabolicHealth #LipidEnergyModel #HeartFailure #LPa #GLP1 #TrialDesign #Cardiology #LowCarb #BloodWork
- 2 weeks ago2h 40m
Darius Sharp – Pt 2 – What Happens to Your Lipids After 2,000 Calories of Fat?
In this episode of The Feldman Protocol, what actually drives cardiovascular disease in a metabolically healthy, lean individual — and is elevated LDL the most important variable to consider? Darius Sharpe (ER nurse and lean mass hypersponder community member) discusses his unexpected CAC score at age 38, his theory on postprandial glucose and vascular damage, a personal episode of atrial fibrillation, the Keto CTA study's Clearly data controversy, and what ER nurses observe firsthand about metabolic illness.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/43` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & CAC score reveal4:51 – Darius's CAC scan background9:07 – First-phase insulin response explained15:47 – CAC result context & vessel findings22:09 – Darius investigates his own cardiac risk33:43 – Atrial fibrillation episode & AFIB physiology43:28 – Electrolytes, magnesium, and sodium discussion51:04 – Stress tests vs. imaging: a patient case58:01 – Metabolic syndrome underdiagnosis in hospitals1:03:09 – Dave's diet experiments & LMHR data1:09:18 – Fat bomb experiment: NMR findings1:20:53 – Lipid energy model & structural hypothesis1:30:37 – Keto CTA: plaque associations & progressors1:39:41 – Clearly data controversy & scientific transparency1:51:55 – Glucose, hyperglycemia, and plaque theory2:05:22 – Raw data release & cards on the table2:15:01 – ER realities & medication safety2:29:07 – Lifestyle, habits, and the ER patient perspective2:39:10 – Where to find Darius & closing thoughts#FeldmanProtocol #DaveFeldman #DariusSharpe #LeanMassHypersponder #KetoCTA #CACScore #AtrialFibrillation #PostprandialGlucose #MetabolicSyndrome #LipidEnergyModel #CardiovascularHealth #CGM #LDL #InsulinResponse #ERNurse #BloodTesting #HeartHealth #NMRPanel
- 3 weeks ago3h 35m
Dr. Malcolm Kendrick – The Country With the Lowest Cholesterol and the Highest Heart Disease Rate
In this episode of The Feldman Protocol, how well does the prevailing understanding of LDL and cardiovascular disease hold up under close scrutiny? Dave sits down with Malcolm Kendrick (MD) — author, researcher, and longtime cardiovascular disease skeptic — who challenges key assumptions across trial methodology, observational data, Mendelian randomization, clinical trial blinding, nitric oxide's role in vascular health, and the response-to-injury model of atherosclerosis.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/46` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open1:11 – Malcolm Kendrick's background6:02 – Early contrarian tendencies in medicine16:48 – International cholesterol skeptic network22:13 – Shifting LDL targets over decades39:05 – FH, heterozygous vs. homozygous49:35 – Examining pharmaceutical trial evidence57:00 – Clinical trial blinding & composite endpoints1:07:27 – Data transparency & CTT access questions1:23:11 – Statins, nitric oxide & plausible mechanisms1:37:34 – Mendelian randomization discussed1:54:43 – Audience questions: ApoB & endothelial injury2:05:24 – Kendrick's cardiovascular disease model2:19:44 – Shared models: vascular repair & hemostasis2:38:39 – The Daily Mail lawsuit: origins2:47:32 – Five-year legal battle & court proceedings3:00:01 – CTT emails & trial methodology concerns3:17:29 – LMHR study update & CLEARLY retraction3:33:23 – Where to find Malcolm Kendrick#FeldmanProtocol #DaveFeldman #MalcolmKendrick #CardiovascularDisease #LDLCholesterol #LipidHypothesis #ClinicalTrials #NitricOxide #Atherosclerosis #StatinResearch #HeartHealth #LeanMassHyperresponder #CholesterolDebate #ApoB #MetabolicHealth #EvidenceBasedMedicine #TrialMethodology #Cholesterol
- Aug 21, 20262h 41m
Sugar Is Wiring Kids' Brains for Lifelong Addiction – Dr. Jen Unwin
In this episode of The Feldman Protocol, what does it take to recognize and address a compulsive relationship with food — and why does that recognition matter so much? Jen Unwin (clinical and health psychologist) joins Dave to explore the psychology of hope in medical settings, her personal history with carbohydrate-driven food behaviors, the evidence behind ultra-processed food addiction as a proposed clinical category, the WHO/ICD recognition process, GLP-1 medications as one potential tool, and why social context and proximity to trigger foods shape outcomes for so many people.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/45` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open1:13 – Jen's background in psychology5:44 – Path to clinical training in Manchester12:47 – Hope as a clinical concept21:28 – Positive psychology & the nun study27:02 – Hope's influence on David Unwin's practice35:23 – Jen's personal food history43:02 – Discovering low-carb & the turning point52:22 – Food addiction: Dave's french fry story1:02:47 – Seeking official recognition of food addiction1:09:01 – Building expert consensus on terminology1:15:55 – Treatment outcomes & published research1:27:47 – Comparing food addiction to tobacco history1:36:05 – Proximity, social pressure & behavior change1:47:08 – Behavioral vs. substance-based framing1:54:52 – Prevalence data & retired athlete findings2:02:23 – Audience questions & GLP-1 medications2:33:39 – Nutrient density, protein, and food as fuel2:39:41 – Where to find Jen & closing remarks#FeldmanProtocol #DaveFeldman #JenUnwin #FoodAddiction #UltraProcessedFood #HopeInMedicine #PositivePsychology #LowCarb #BehaviorChange #DSM #FoodAddictionRecognition #CarbohydrateAddiction #GLP1 #NutrientDensity #MentalHealth #SolutionFocused #MetabolicHealth #Keto
- Aug 14, 20264h 1m
Dr. David Unwin: Low Carb, Diabetes & Food Addiction
In this episode of The Feldman Protocol, how does one family doctor's decades-long frustration with a "progressive, incurable" disease lead to a fundamentally different approach to patient care? Dave Feldman and David Unwin (MD) explore the pivotal 2012 patient encounter that reshaped Unwin's practice, the psychology of behavior change and food addiction, real-world data from a 10,000-patient NHS cohort, collaborative medicine versus authoritarian care, GLP-1 drugs as a last resort, and AI's emerging role in clinical decision-making.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/44` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open1:24 – David Unwin's background13:07 – Generational health trends observed20:19 – Conventional medicine & early career39:14 – The art vs. science of medicine52:28 – The ACCORD study discussed1:04:45 – The 2012 pivotal patient encounter1:17:13 – Publishing the first 18-patient audit1:30:06 – Unexpected behavioral changes on diet1:45:09 – Collaborative medicine & patient partnership2:02:32 – Evolutionary context for modern diet2:13:06 – Food addiction & maintenance challenges2:35:12 – GLP-1 drugs: a nuanced discussion2:47:23 – Questions from the desk3:09:27 – Unwin's real-world remission data3:16:03 – AI in medicine & society3:44:36 – Technology, freedom & human adaptability3:59:46 – Closing & where to find David Unwin#FeldmanProtocol #DaveFeldman #DavidUnwin #LowCarb #MetabolicHealth #Type2Diabetes #DiabetesRemission #BehaviorChange #FoodAddiction #CollaborativeMedicine #NHSData #GLP1 #NutritionalScience #InsulinResistance #RealWorldData #PublicHealthCollaboration #LowCarbGP #AIInMedicine #FamilyMedicine
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About The Feldman Protocol
Dave Feldman hosts the Feldman Protocol, a long form, in-person podcast largely covering science, nutrition, and technology – with a lot of personal stories, interests and pop culture mixed in.
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