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Innovate and React: Daily Summaries Delivered
by Kevin Hares
Talking to scientist about their innovations in chemistry
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- 2 days ago50 min
How Copper Catalysts Unlock Unreactive Molecules for Hydrogenation
In this episode of Innovate and React, I welcome Professor Johannes Teichert from TU Chemnitz, spokesperson of the CATALOOP network, to explore how cheap, abundant metals like copper can replace precious noble metals in catalysis. While traditional cross-coupling reactions have long dominated pharmaceutical synthesis, which resulted in a world of relatively flat drug molecules, while modern catalyst development is unlocking entirely new three-dimensional molecular scaffolds. However, replacing active metals like rhodium and iridium with copper presents a massive reactivity hurdle, especially when targeting challenging functional groups like conjugated amides. These were previously deemed completely unreactive by the scientific literature for copper hydride chemistry. We discuss the interplay between fundamental academic freedom and applied industry needs, and how tackling these "impossible" substrates could eventually eliminate wasteful stoichiometric reagents in favor of sustainable, hydrogen-driven reactions. How do you trick an unreactive copper complex into unlocking these inert building blocks without relying on extreme pressures and specialized autoclaves? Johannes reveals the serendipitous conference meetup that inspired a new class of bifunctional ligands, though a few puzzle pieces in their exact catalytic mechanism still remain to be solved. We also dive into how this gentle, balloon-pressure chemistry opens the door for a wider group of labs and late-stage deuterium labeling in complex drug discovery. Also we cover why "failed" lab experiments are suddenly becoming valuable assets in data driven approaches within the EU-funded CATALOOP network, and which groundbreaking historical lab moment Johannes wishes he could have witnessed firsthand.
- Aug 26, 202640 min
Replacing crude oil with local plants to make chemicals
In this episode of Innovate and React, I welcome my former PhD mentor, Dr. Thomas Seidensticker from TU Dortmund, to explore how oleochemistry can provide a sustainable, locally grown alternative to crude oil for the chemical industry. While the traditional chemical sector relies heavily on cheap fossil fuels, plant oils naturally offer closely related hydrocarbon chains that can be functionalized for everyday products like surfactants, cosmetics, and polymers. However, shifting away from crude oil presents the unique challenge of dealing with complex, inhomogeneous fatty acid profiles that constantly vary by plant origin and season. We discuss the strategic importance of feedstock sovereignty and how diverting plant oils from low-value biodiesel combustion into long-lasting chemical products can create vital carbon sinks to help meet future renewable carbon targets. How do you transform these varied plant oils into the standardized building blocks the conventional industry demands? Thomas explains the breakthrough potential of utilizing the unsaturated carbon-carbon double bonds in plant oils, highlighting technologies like cross-metathesis and his own university spinoff, Simplyfined. We also dive into the historical 1938 roots of homogeneous catalysis, the logistical hurdles of scaling pilot volumes, and why agile startups are essential for taking the disruptive technological risks that large, slow-moving chemical corporations currently avoid.
- Jul 28, 202637 min
Replacing chemical plants with methanol-eating bacteria
In this episode of Innovate and React, I welcome Dr. Ronja Rappold, co-founder of TENO Bioworks, to explore how microorganisms and synthetic biology can transform alternative carbon sources into high-value chemicals. While biological manufacturing is well known for producing life-saving pharmaceuticals like insulin or traditional fermented goods, shifting base and fine chemical production away from fossil fuels presents a unique challenge. Relying solely on agricultural sugars introduces significant "food vs. fuel" conflicts and risks breaching critical planetary boundaries, including land use, freshwater consumption, and nutrient cycles. Ronja and her team address this by targeting C1 feedstocks—specifically green methanol derived from captured CO₂. How do you teach an industrial workhorse to live on a completely foreign feedstock? Ronja explains TENO Bioworks' approach to performing a metabolic "heart transplant" on Escherichia coli (E. coli). They successfully rewired E. coli to utilize methanol as its primary carbon and energy source. We also dive into the downstream engineering required to produce target chemicals like lactic acid, the advantages of using raw, unpurified methanol over traditional metal catalysts.
- Jul 9, 202640 min
Defying Markovnikov: A New Spin on the Wacker Oxidation
In this episode of Innovate and React, I welcome back Thomas Bouveyron from and TH Köln to explore how we can make conventional petrochemical pathways more sustainable. We look into the synthesis of n-decanal, which is a crucial molecule in the fragrance industry and a key scent in Chanel No. 5. Thomas' gaol is to shift from crude oil- to bio-based building blocks. How do you bend the rules of classical Wacker oxidation to favor the usually unfavored anti-Markovnikov product? Thomas shares his methodology, combining statistical Design of Experiments (DOE) and computational Density Functional Theory (DFT) calculations to unravel more of the catalytic mechanism. We also discuss the practical engineering hurdles of catalyst fatigue, solvent participation, and the tricky business of separating decanal from decanone.
- Jun 15, 202655 min
The Perfect Compromise: Unlocking the Future of Green Hydrogen with AEM
In this episode of Innovate and React, I met with Miriam Hesse and Bastian Kaufmann, researchers at the Hydrogen and Fuel Cell Center (ZBT) to discuss the rising potential of Anion Exchange Membrane (AEM) water electrolysis. We explore how AEM serves as the perfect compromise between traditional alkaline systems and proton exchange membrane (PEM) electrolysis, offering high efficiency without the reliance on expensive precious metals like platinum and iridium. Miriam and Bastian share their journey into hydrogen research and how ZBT acts as a crucial bridge between fundamental chemistry and applied industrial engineering across the entire hydrogen value chain. The conversation dives deep into the specific challenges and innovations within AEM technology, from navigating the historical bottlenecks of polymer membrane stability to the intricate process of fabricating homogeneous catalyst layers directly onto porous transport layers (PTLs). We discuss the promising use of nickel-based catalysts to optimize the oxygen and hydrogen evolution reactions. Furthermore, we examine the complexities of scaling this technology for industry, emphasizing the need for long-term degradation data, accelerated stress tests, and advanced analytical methods like electrochemical impedance spectroscopy (EIS) and the distribution of relaxation times (DRT) to pinpoint exactly where performance losses occur in real-world systems.
- May 22, 202627 min
Stopping PFAS at the Source: Innovating Industrial Wastewater Treatment
In this episode of Innovate and React, I met with Dr. Rhea Machado, the CEO and co-founder of Porelio, to discuss their solution for removing forever chemicals from our drinking water. We explore the widespread issue of PFAS accumulating in our water, our food, and even unborn children, and how short-chain PFAS remain a massive challenge because traditional methods like activated carbon and ion exchange resins fail to capture them. Rhea shares Porelio's journey as a spinoff from the Technical University Berlin, where they took highly efficient but traditionally hard-to-produce functionalized ordered meso-porous silica and successfully scaled it for industrial use. The conversation dives deep into Porelio's innovative approach, which uses an ordered pore structure equipped with engineered functional groups to quickly and selectively catch specific target molecules, whether that is toxic PFAS in industrial wastewater or valuable precious metals. We discuss the multifaceted challenges of scaling a B2B chemistry startup, from defining unit economics to simultaneously scaling production and navigating regulatory pathways like REACH, all while trying to find innovative R&D partners in a conservative industry.
- Apr 28, 20261h 9m
Beyond Fertilizer: The Future of Low-Emission Ammonia
In this episode of Innovate and React, I met with Kevin Rouwenhorst, the technology manager at the Ammonia Energy Association, to discuss the future of sustainable ammonia synthesis. We explore his journey into the clean molecule space, which ultimately led him to write a comprehensive book on low-emission ammonia technologies. Kevin clarifies a common misconception about the traditional Haber-Bosch process, explaining that over 90% of its CO2 emissions actually stem from hydrogen production, such as steam methane reforming or coal gasification, rather than the ammonia synthesis loop itself. The conversation dives deep into the challenges of decarbonizing this massive industry, focusing on the high costs of scaling green electrolytic hydrogen and the complexities of retrofitting existing plants for carbon capture. We discuss the engineering hurdles of designing flexible ammonia plants that can adapt to the variable loads of renewable energy sources. Beyond its traditional use in fertilizers, we explore exciting emerging use cases for low-emission ammonia, including its adoption as a zero-carbon maritime fuel, and its potential for power generation, such as co-firing in thermal plants and fueling combined cycle gas turbines. The episode concludes with a look at safety standards, the geopolitical implications of localizing energy production, and the fascinating history behind the Haber-Bosch process and Alwin Mittasch's catalyst discovery.
- Apr 14, 202643 min
Scaling Sustainable Chemistry: How Startups Can Transform the Industry
In this episode of Innovate and React, I met with Stefan Weber and Martin Bellof, the founders of Chemstars, to discuss how to overcome common hurdles for founders in the chemical space. We explore the massive transformation currently underway in the chemical industry. Startups are a vital missing puzzle piece to help the industry move toward circularity, climate neutrality, and industrial resilience. Stefan and Martin explain how they help connect the startup ecosystem with the chemical industry to bring scientific innovations from the lab to the market. The conversation dives deep into the specific challenges chemistry founders face, such as lacking industry know-how, navigating a highly regulated market, and securing the capital needed to scale technical processes from the lab to industrial facilities. The episode concludes with actionable advice on the importance of getting out of the lab to validate ideas with potential customers. We also discuss the need to simplify complex science through storytelling and how to leverage early-stage networks.
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