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by Jim O'Shaughnessy
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- 3 days ago1h 43m
Mykhailo Marynenko - AI Tools That Give Creators More Control (Ep. 314)
Mykhailo Marynenko joins Infinite Loops for for a fascinating conversation about the future of AI, creative tools, privacy, and data ownership. From growing up in his father's phone repair shop in Ukraine to building experimental AI systems today, Mykhailo has spent his life taking things apart, figuring out how they work, and rebuilding them in unexpected ways. We explore how AI can help creators without replacing them, why privacy and data ownership matter, and what it means to design tools that give people more control over complex information. Important Links More about Misha: https://linktr.ee/0x77dev?utm_medium=mykhailo.link
- 1 weeks ago1h 52m
Danielle Crittenden - Dispatches from Grief (Ep. 313)
On a February morning, Danielle Crittenden's world cleaved in two: the life before her daughter Miranda was found dead in her Brooklyn apartment, and the life after. Two years and three months later, Danielle joins Infinite Loops to discuss her luminous memoir, Dispatches from Grief, which unflinchingly traces the strange afterlife of grief with precision, restraint, and unexpected humor. This conversation explores what grief really feels like. With extraordinary honesty and grace, Danielle shares the physical pain, the loneliness of loss, and the slow work of carrying her daughter's memory forward. Dispatches from Grief is out now: Infinite Books | Amazon Danielle's Substack: The Femsplainers With Danielle Crittenden
- 2 weeks ago1h 25m
Saloni Dattani - The Hidden Bottleneck Holding Back the Future of Medicine (Ep. 312)
Saloni Dattani, author of the Scientific Discovery Substack and founding editor of Works in Progress magazine, joins Infinite Loops to discuss why medical innovation is often much slower than it needs to be. We explore why so much research still begins in animal models, how poor data distorts our understanding of disease, why clinical trials are one of the biggest bottlenecks in medicine, and how better systems could help promising treatments reach patients faster. Important Links: Read more from Saloni here: https://worksinprogress.co/our-authors/saloni-dattani And here: https://substack.com/@salonium And listen to Saloni's podcast "Hard Drugs" here: https://harddrugs.worksinprogress.co/
- 3 weeks ago1h 13m
Brian Potter - How to Fix America's Building Problem
Why has America become so bad at building housing, infrastructure, and major projects? Brian Potter, author of The Origins of Efficiency and writer of Construction Physics, explains why prefab housing keeps failing and why there are no easy fixes to America's building problem. We discuss Katerra, California's anti-growth turn, and the deeper logic behind local opposition to growth: concentrated harms and diffuse benefits. Important Links: Read Brian's newsletter Construction Physics here: https://www.construction-physics.com/ Read Brian's book The Origins of Efficiency here: https://press.stripe.com/origins-of-efficiency Learn more about Brian here: https://ifp.org/author/brian-potter
- Apr 16, 20261h 36m
Alex Petkas - What Ancient Greece Can Teach Us About AI and the Future (Ep. 310)
What can Aristotle, Plato, Prometheus, and the Greek city-states teach us about AI, innovation, and the future of human flourishing? Alex Petkas joins the show to explore how old myths still matter in a world shaped by technology. We talk about Prometheus as the foundational myth of tech, Plato's fear that writing would become a tool for forgetting, the real lesson of Icarus, why decentralization creates cultural power, and what it means to remain fully human in the age of AI. Important Links: Learn More about The Cost of Glory: www.costofglory.com Check out Alex's Youtube Channel: https://www.youtube.com/@costofglory Alex's Twitter: https://x.com/costofglory The Cost of Glory Substack: https://costofglory.substack.com/
- Apr 9, 20261h 46m
Sam Arbesman - Why Future Belongs to Curious People (Ep. 309)
Scientist and writer Sam Arbesman joins us for a wide-ranging conversation on AI, optimism, science, education, archives, science fiction, and why the history of computing still has so much to teach us. We talk about why pessimism is often mistaken for sophistication, why AI may reward open-mindedness more than intelligence, why science works even though scientists are imperfect, and why the future may depend on revisiting forgotten ideas from the past. Important Links: Learn more about Sam here: https://arbesman.net/ Read Sam's latest book: https://www.hachettebookgroup.com/titles/samuel-arbesman/the-magic-of-code Sam's Substack: https://arbesman.substack.com/about Neal Stephenson's Innovation Starvation: https://www.wired.com/2011/10/stephenson-innovation-starvation/ David Deutsch's The Beginning of Infinity: https://www.thebeginningofinfinity.com/
- Apr 2, 20261h 39m
Johnathan Bi - Why the Best Founders Might Need a Little Delusion (Ep. 308)
Johnathan Bi returns to Infinite Loops for a conversation about founders, delusion, America, religion, mysticism, and the strange tension between truth and action. We explore why some of the most effective builders may be the least introspective, why societies often run on useful fictions, how America encourages megalomania, what happens when materialism starts to feel incomplete, and why the "seeker" may matter even more in the age of AI. The episode moves from Plato and Caesar to founders, mystics, near-death experiences, and the future of human creativity. Important Links: Johnathan's Youtube Channel: https://www.youtube.com/@bi.johnathan Johnathan's Substack: https://substack.com/@johnathanbi
- Mar 26, 20261h 7m
Polina Pompliano - What Truly Drives Successful People (Ep. 307)
Polina Pompliano studies some of the most successful people in the world—and what she's found challenges how we think about success, creativity, and human behavior. In this episode of Infinite Loops, we explore the mental models behind high performers, why we misunderstand people (including ourselves), and what it really takes to see the world differently. From creativity and rationality to identity, media bias, and the hidden motivations driving success, this conversation is a deep dive into how great thinkers actually operate. Important Links: Check out Polina's new book: https://www.amazon.com/Hidden-Genius-Thinking-Successful-People/dp/0593715604 More from Polina Pompliano — The Profile: https://theprofile.substack.com
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About Infinite Loops
Every Thursday, join Jim O'Shaughnessy and his favorite people as they arm you with the tools & fresh perspectives required to upgrade your HumanOS and thrive in our messy, probabilistic world.Visit our Substack at newsletter.osv.llc for full transcripts, highlights, weekly doses of timeless wisdom, and a bounty of other goodies designed to make you go, "Hmm that's interesting!"
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