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by Josh Turknett, MD
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- 1 weeks ago28 min
Can This Vaccine Help Prevent Alzheimer's?
Can a shingles vaccine cut your dementia risk by 20%? A series of landmark studies — published in Nature, Cell, and JAMA — say yes. In this episode, Tommy unpacks the research: how natural experiments in four countries produced one of the most compelling signals in dementia prevention, what might explain the effect beyond infection prevention, and what it means for your own vaccination decisions. In this episode: 00:00 — Introduction 00:52 — The new data on shingles vaccination and Alzheimer's risk 01:48 — The Stanford group and their regression discontinuity methodology 03:15 — How birthday-based eligibility creates a natural experiment (Wales, Canada, Australia) 05:28 — Results: a ~20% reduction in dementia diagnoses across all countries 06:52 — The Cell paper follow-up: benefits at every disease stage (unimpaired → MCI → dementia) 07:55 — Shingrix vs. Zostavax: the US natural experiment and a potentially larger effect 09:08 — Why does it work? Preventing illness, avoiding bed rest and disuse, immunomodulation 11:29 — Neuroinflammation and possible immune system "tuning" effects 12:27 — The sex difference: greater benefit in women in most (but not all) studies 15:52 — Summary of the evidence and what it means for dementia prevention strategy 17:36 — Josh's take: number needed to treat analysis 19:15 — Heterogeneous pathways to dementia and why vaccination fits the toolkit 21:13 — Practical advice: when to get vaccinated, repeat dosing, and personal risk assessment 25:36 — Wrap-up and how to submit questions Links & Resources: Shingles vaccine and dementia studies: Nature (Wales, 2025), Cell (Wales follow-up), JAMA/Lancet (Canada, Australia, US) Flu vaccine and dementia: Neurology (2026) Tommy's book: The Stimulated Mind To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
- Apr 14, 202628 min
Can a Blood Test Predict Alzheimer's?
A recent study published in Nature Medicine claims a blood test can predict when you'll develop Alzheimer's disease, and it got a lot of attention. But how well does it actually work, and should you rush out and get tested? In this episode, we break down the study behind the headlines to understand what it really shows, where the major limitations lie, and what it means for anyone thinking about getting this kind of test. Topics and Questions Covered What P-Tau 217 is and why it's become the leading blood-based biomarker in Alzheimer's research. How researchers built a predictive "clock" from blood test data and what that process required. The important distinction between having pathology in your brain and actually developing dementia. Who should and should not be getting tested. What a large Norwegian population study reveals about the overlap between pathology and normal cognitive function. How biomarkers like this might eventually fit into a broader, more personalized approach to prevention. and more! -------------- To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
- Feb 28, 202621 min
An Existential Crisis for Alzheimer's Research?
In this episode, we discuss a study published in PLOS One that compared living brain tissue to post-mortem brain tissue and found dramatic molecular differences between the two. The findings raise serious questions about decades of Alzheimer's research built on post-mortem analysis and may help explain why pharmaceutical treatments for the disease have been so disappointing Study: A Study of RNA Splicing and Protein Expression in the Living Human Brain -------------- To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
- Feb 10, 2026
Video Games That Boost Brain Function
In this episode, we explore a rigorous meta-analysis examining how action video games, particularly first and third-person shooters, affect cognitive function in young adults. The research reveals promising evidence that these games can enhance processing speed and selective attention, with the strongest benefits coming from games requiring rapid environmental responses and decision-making under time pressure. What we discussed: How action video games like Halo and Call of Duty improve processing speed and selective attention more than traditional brain training apps Why games requiring rapid responses to the environment create cognitive benefits that are hard to replicate in daily life The specific game features that matter most: unpredictable environments, time pressure, and rapid response demands Practical game recommendations for adults new to gaming, including accessible options on Nintendo Switch and modern smart TVs How to balance gaming benefits with potential downsides like sleep disruption and social isolation To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
- Jan 30, 202629 min
Does Computerized Brain Training Help?
In this episode, we dig into a recent McGill University study on computerized cognitive training and its effects on brain chemistry in older adults. What you'll learn: Why certain brain training games reversed a decade of age-related cognitive decline in just 10 weeks—and how researchers finally measured actual biological changes in the brain The critical difference between activities that genuinely enhance your brain versus mental junk food like Candy Crush or Solitaire The single organizing principle you can use to evaluate whether any cognitive activity is actually helping your brain or wasting your time To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
- Jan 16, 202634 min
What's Wrong With The New Food Pyramid.
In this episode, we dive into guidelines to figure out what all the fuss is about, whether that fuss is warranted, and whether we should even be issuing dietary guidelines to begin with! Topics and Questions Covered The updates: A breakdown of the specific shifts regarding protein prioritization, full-fat dairy, and whole grain recommendations. The visual shift in nutrition: The transition from the "MyPlate" model to the inverted pyramid visual and the symbolism and subtext behind the change. Individualization vs. Population health: Why a "one-size-fits-all" approach to nutrition often fails to account for individual metabolic variation. The problem with food classification: Why our archaic food categories generate needless confusion and controversy. Internal contradictions: Identifying inconsistencies within the guidelines Subsidies and accessibility: The economic misalignment between government dietary advice and agricultural subsidies for ultra-processed food ingredients. Communication challenges: The difficulty of maintaining scientific nuance in a public health messaging environment. To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.
- Dec 18, 202523 min
#90: This Brain Aging Study Is Our New Favorite!
Much of what we talk about on Better Brain Fitness resolves around the demand-driven decline model we published. Well...a new study just published in Nature Communications gave that model the best test to date, and the results are pretty darn exciting. So of course we had to do an episode about it! The study looks at the relationship between brain aging and creative activities like music, dance, art, and video gaming. Tommy walks through the study and explains why this matters for anyone thinking about their long-term cognitive health. What You'll Learn: A more sensitive way to measure brain aging than structural scans The connection between music, dance, art, and video gaming on brain aging The effect of 30 hours of video gaming on brain aging, the kinds of video games that have the greatest impact (and why traditional "brain games" haven't been as successful) What this research tells us about whether cognitive decline is reversible The dose-response relationship between complex activities and brain health To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.
- Dec 12, 202526 min
#89: How to Neutralize the Impact of Hearing Loss on Dementia Risk
In this episode, we tackle a question from listener Carolyn in Michigan about the potential cognitive impacts of long-term hearing loss. What You'll Learn: The research linking hearing loss to increased dementia risk and what the evidence actually shows How hearing aids impact the risk of cognitive decline The mechanisms behind why hearing loss might affect brain health Practical strategies for maintaining cognitive health when dealing with hearing loss Innovative technologies for hearing loss that could provide new forms of cognitive stimulation To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.
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About Better Brain Fitness (a Brainjo Production)
Hosted by Drs. Josh Turknett and Tommy Wood, Better Brain Fitness explores the frontiers of how to keep our brain fit and healthy, so that we can perform at our best and do the things that we love for as long as possible.
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