Wits & Weights | Evidence-Based Fitness & Nutrition for Lifters Over 40

The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

April 21, 2026·31 min
Episode Description from the Publisher

What REALLY happens when you take a GLP-1 drug? Your fat loss, your muscle, your heart, your inflammation, what happens to your weight when you stop, and long-term safety. This episode covers body composition data from the 2026 semaglutide and tirzepatide trials, cardiovascular outcomes from SELECT and SURPASS-CVOT, inflammation findings beyond weight loss, weight regain patterns after stopping, and a 5-part framework to keep muscle on or off the drug after 40. Plus the 2026 safety upda...

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