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This Week in Neuroscience: Daily Summaries Delivered
by Vincent Racaniello
A podcast about the nervous system.
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The most recent episodes — sign up to get AI-powered summaries of each one.
- 1 weeks ago1h 19m
TWiN 76: Light Switches Go To Stockholm
TWiN explains the science behind the 2026 Nobel Prizes in Physiology or Medicine for discoveries on light-gated ion channels and optogenetics. Hosts: Vincent Racaniello and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Nobel Prize Physiology or Medicine 2026 (Nobel) Driving fast-spiking cells (Nature) Manipulating synthetic optogenetic odors (Science) Microbial rhodopsin in mammalian neurons (Nat Methods) Deisseroth lectures on optogenetics (iBiology) Cardiogenic control of affective behavioral state (Nature) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
- Sep 29, 20261h 8m
TWiN 75: Arc, tau, and Alzheimer's
Jason Shepherd joins TWiN to discuss the work in his laboratory showing that Arc protein plays a role in intercellular transmission of tau protein, which becomes hyperphosphorylated and misfolded, a major histopathological hallmark of Alzheimer's disease. Hosts: Vincent Racaniello and Tim Cheung Guest: Melissa Cooper Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Arc and Tau intercellular transmission (Cell) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
- Jul 30, 20261h 6m
TWiN 74: Plastic astrocyte networks with Melissa Cooper
Melissa Cooper joins TWiN to discuss her discovery that astrocytes connect specific brain regions through plastic networks. Hosts: Vincent Racaniello and Tim Cheung Guest: Melissa Cooper Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Astrocytes form plastic networks (Nature) Newly found brain network (Nature) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
- Jun 25, 20261h 26m
TWiN 73: The price of a bigger brain
TWiN unpacks a striking paradox, that the very cell divisions that built the human brain's most advanced layers also put them at greatest risk, and how a dedicated DNA repair pathway saves them. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair (Nature) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
- Jun 1, 20261h 9m
TWiN 72: What cesarean babies miss
TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin. .Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits (Cell Host Microbe) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
- Apr 29, 20261h 31m
TWiN 71: Psychedelics rewire the brain from within
TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Psychedelics rewire the brain from within (Science) Psychedelics elicit their effects by Gi signaling (Nature) History of LSD (Wikipedia) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
- Mar 17, 20261h 19m
TWiN 70: Unraveling the axon wrap
TWiN explains the role of a ubiquitin ligase component in regulating the sheathing of multiple axons by Schwann cells. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Gut microbiome promotes pain in fibromyalgia (Neuron) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
- Mar 5, 20261h 11m
TWiN 69: Fibromyalgia and the microbiome
TWiN explains a study which showed that transplanting gut microbiota from women with fibromyalgia into mice induces pain, as well as phenotypes commonly observed in patients, such as immune activation, metabolomic changes, and reduced skin innervation. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Gut microbiome promotes pain in fibromyalgia (Neuron) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
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About This Week in Neuroscience
A podcast about the nervous system.
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