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by Dr. Neil Love
Medical oncologist Dr Neil Love interviews clinical investigators on new research and practical application to general medical oncology practice.
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Featuring perspectives from Dr Gottfried E Konecny and Dr Brian M Slomovitz, including the following topics:Introduction Preventing Ovarian Cancer Endometrial Cancer Ovarian Cancer Cervical Cancer CME information and select publications
Featuring perspectives from Dr Alexandra Drakaki, including the following topics:Case: A man in his late 70s with diabetes and metastatic bladder cancer achieves radiographic response with enfortumab vedotin (EV) and pembrolizumab but develops uncontrolled hyperglycemia Case: A man in his early 70s with muscle-invasive bladder cancer receives adjuvant nivolumab and experiences metastatic progression after 9 cycles of therapy Case: A woman in her early 70s with Lynch syndrome and metastatic upper tract bladder cancer receives EV/pembrolizumab and develops myasthenia gravis Case: A woman in her late 40s with FGFR3 mutant metastatic bladder cancer receives erdafitinib and experiences rising serum phosphate levels CME information and select publications
Featuring perspectives from Dr Alexandra Drakaki, including the following topics:Case: A man in his early 80s with bladder cancer and metastatic progression in the viscera and lymph nodes receives enfortumab vedotin (EV) with pembrolizumab — Part 1 Case: A man in his early 80s with metastatic bladder cancer achieves a complete response with EV/pembrolizumab therapy but develops gastrointestinal toxicity — Part 2 Case: A man in his early 50s with metastatic bladder cancer receives second-line EV monotherapy intermittently Case: A woman in her mid 60s with bladder cancer and a history of rheumatoid arthritis develops oligometastatic progression in the lung and receives EV monotherapy Case: A man in his mid 80s with HER2-positive (IHC 3+) metastatic bladder cancer receives trastuzumab deruxtecan and develops ground glass opacities in his lungs concerning for pneumonitis CME information and select publications
Featuring perspectives from Dr Aditya Bardia, Dr Kevin Kalinsky and Dr Joyce O'Shaughnessy, including the following topics:Introduction Hormone Receptor-Positive Breast Cancer — Dr Kalinsky HER2-Positive Breast Cancer — Dr Bardia Triple-Negative Breast Cancer — Dr O'Shaughnessy CME information and select publications
Featuring perspectives from Dr Rachel N Grisham, including the following topics:Case: A woman in her early 40s with recurrent low-grade serous ovarian cancer (LGSOC) and prior treatment with a MEK inhibitor receives avutometinib/defactinib on the RAMP 301 trial Case: A woman in her early 70s with recurrent KRAS-mutated LGSOC receives avutometinib/defactinib and develops muscle weakness Case: A woman in her late 70s with KRAS-mutated recurrent LGSOC develops congestive heart failure on trametinib and then receives avutometinib/defactinib Case: A woman in her mid 60s with recurrent BRAF V600E LGSOC has concerns about side effects and receives single-agent dabrafenib CME information and select publications
Featuring perspectives from Dr Rachel N Grisham, including the following topics:Mechanism, clinical evidence and practical use of avutometinib with defactinib for recurrent low-grade serous ovarian cancer (LGSOC) A Phase III trial of letrozole alone as front-line treatment for LGSOC Current and future role of avutometinib with defactinib for LGSOC A Phase II/III trial of trametinib for recurrent LGSOC: Biomarker analyses and clinical implications CME information and select publications
Featuring an interview with Prof Andreas Hochhaus, including the following topics:Biology of chronic myeloid leukemia (CML) and rationale for current therapeutic approaches; importance of cytogenetic testing Mechanistic differences among first-generation tyrosine kinase inhibitors (TKIs), second-generation TKIs and asciminib Potential mechanisms of adverse events documented with TKIs Recent survey of patients with CML regarding goals of therapy and clinical implications; considerations for discontinuation of therapy Comparative tolerability of asciminib and other agents used to manage CML; promoting adherence to treatment plans for patients Comparative efficacy of asciminib and other agents used to treat CML Potential areas for improvement in community oncology practice patterns; family planning in the context of CML treatment Practical care strategies for CML patients; future developments CME information and select publications
Featuring perspectives from Dr Floor J Backes, Dr Matthew A Powell and Dr Ritu Salani, moderated by Dr Salani, including the following topics:Case: A woman in her late 60s with recurrence of metastatic estrogen receptor-positive endometrial cancer enrolls in a trial of CDK4/6 inhibition with an aromatase inhibitor 1 year into maintenance dostarlimab after carboplatin/paclitaxel/dostarlimab and has no evidence of disease 3 years later Adding a PARP inhibitor to immunotherapy and chemotherapy: The RUBY Part 2 and DUO-E trials CME information and select publications
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Medical oncologist Dr Neil Love interviews clinical investigators on new research and practical application to general medical oncology practice.
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