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JHLT: The Podcast: Daily Summaries Delivered
by ISHLT
The Journal of Heart and Lung Transplantation podcast features the JHLT Digital Media Editors in round table talks with the Journal's contributors.
Latest Episodes
The most recent episodes — sign up to get AI-powered summaries of each one.
- 3 days ago13 min
Episode 95: Cytotoxic T Cells and Transcriptional Priming in Lung Transplantation
Today's JHLT: The Podcast features a recent article on a pediatric cohort in JHLT: "Cytotoxic CD8+ T cells persist and show transcriptional priming in lung transplantation." Today's guest is senior author Don Hayes, Jr., MD, MS, Med, MBA, ISHLTF, of the Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine. The discussion with Dr. Hayes explores: The fascinating behavior and persistence of CD8+ T-cell clones in the cohort What we know—and don't know—about these cells' role in inflammation and allograft rejection Therapeutic and clinical considerations for patients displaying these T-cells The future of the research, including further validation, surveillance, and precision immunosuppression For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
- 2 weeks ago28 min
Episode 94: ISHLT Consensus: Frailty in Candidates for Lung Transplant
JHLT: The Podcast continues its exploration of recent consensus documents this month by discussing "Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement." The statement appears online now at JHLT, and a helpful companion perspective piece from the authors can be read in your October print issue of the Journal. Today's guests are project leads Michaela Anderson, MD, MS, of the Hospital of the University of Pennsylvania, and Jonathan Singer, MD, MS, of the University of California San Francisco. In their discussion, they cover: What real-world teams want to know about frailty and how their document enhances clinical capacity How programs decide which tools to use to use to measure frailty—and which are most relevant to lung transplantation The importance of—and best timing for—universal assessment What's next in studying frailty Stay up to date with official standards and guidelines documents from ISHLT at ISHLT.org. For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
- Oct 7, 202633 min
Episode 93: ISHLT Consensus Document: BLAD Definition, Timing, Outcomes
Today, JHLT: The Podcast discusses the recent ISHLT consensus document "Baseline Lung Allograft Dysfunction: Definition, Timing, and Implications for Outcomes—An ISHLT Consensus Document." Now available online at JHLT—and a helpful companion perspective piece from the authors appears in the print October issue of JHLT. Today's guests are co-leads on the document, Jens Gottlieb, MD, of Hannover Medical School and Kieran Halloran, MD, MSc, of the University of Alberta. They discuss: Why rapid increases in usage of "BLAD" in the literature meant it was time for a formal definition Major considerations and areas of debate during the writing process How clinicians should think about patients meeting the criteria for BLAD and how the evaluation of underlying etiologies took place Interpreting BLAD's potential relationship to CLAD Stay up to date with official standards and guidelines documents from ISHLT at ISHLT.org. For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
- Sep 16, 202616 min
Episode 92: Treating PPAS with Stent-Based Pulmonary Angioplasty
In this episode, JHLT: The Podcast continues the Pulmonary Hypertension theme for the month, exploring the study "Long-Term outcomes of stent-based pulmonary angioplasty for isolated peripheral pulmonary artery stenosis," which appears in the September print issue of JHLT. Today's guest is author Hiroto Shimokawahara, MD, of the Okayama Medical Center in Japan. Dr. Shimokawahara's discussion with Digital Media Editor Van-Khue Ton covers: What the study contributes to the clinical literature with longer-term outcomes of stent-based pulmonary angioplasty in peripheral pulmonary artery stenosis (PPAS) How the diffuse nature of PPAS and the advanced stage of disease complicates treatment options The evolution of stent choices and technologies in the last 20 years of clinical practice at their center Ideal follow-up conditions for monitoring patients after PPAS stenting For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
- Sep 2, 202613 min
Episode 91: Medical Therapy Pre- and Post-Pulmonary Endarterectomy
Today, JHLT: The Podcast discusses "Long-term effects of medical therapy pre- and post-pulmonary endarterectomy—insights from the UK CURATE registry," a manuscript available online now and in the September print issue of JHLT. Today's guest is first author Paula Appenzeller, MD, of the National Pulmonary Vascular Diseases Unit at Royal Papworth Hospital in Cambridge. In the episode, Dr. Appenzeller and the editors discuss: How findings from the UK CURATE registry challenge assumptions about pre-operative therapy in CTEPH What's important about the 6-minute walk distance test How hemodynamics help guide post-PEA treatment decisions If multimodal CTEPH treatment could become the norm For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
- Aug 19, 202611 min
Episode 90: The ASSIST CLAD Study: Using Mesenchymal Stromal Cells in New-Onset CLAD
In this episode, JHLT: The Podcast explores the study "The ASSIST CLAD study: A phase 2 randomized controlled trial of mesenchymal stromal cells for new-onset chronic lung allograft dysfunction," which appears in the August print issue of JHLT. Today's guest is Daniel C. Chambers, MBBS, MD, of The Prince Charles Hospital and Queensland Lung Transplant Service in Brisbane, Australia. From across the dateline, he and Digital Media Editor Erika Lease discuss: What inspired the team to explore the use of mesenchymal stromal cell (MSC) infusions in CLAD patients Preparation and treatment considerations for using MSCs How despite the negative outcome—the MSCs made no clear improvements in the patient groups—the study still pushes the field forward For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
- Aug 5, 20267 min
Episode 89: Improved Outcomes and Utilization in Hearts With 10° Static Cold Storage
Today, JHLT: The Podcast discusses "Improved outcomes and donor utilization in heart transplantation with 10 °C static cold storage," a manuscript available online now and in the August print issue of JHLT. Today's guest is senior author John Trahanas, MD, of the Vanderbilt University School of Medicine in Nashville, TN USA. In the episode, Dr. Trahanas and the editors discuss: What was learned from the lung 10°C trials and how the team adapted the devices for hearts The improved outcomes in PGD and survivability observed in the 10°C group How to determine if switching from ice to 10°C actually changed donor selection practices—and how it enabled the team to use more hearts For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
- Jul 15, 202613 min
Episode 88: Looking Back: Is Sotatercept Safe in Patients with PAH?
In case you missed it, JHLT: The Podcast is re-releasing a past audience favorite for your listening pleasure. This month, we revisit a conversation regarding a study from the April 2025 issue of JHLT about the efficacy and safety of sotatercept in patients with PAH. This conversation with Ioana Preston, MD, of the Tufts University School of Medicine in Boston, explores: What makes sotatercept unique as the first "biologic" in the treatment of PAH Hypotheses about the mechanism of action in sotatercept Sotatercept's interaction with mPAP and what it indicates about the drug's action on the pulmonary vasculature For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.
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About JHLT: The Podcast
The Journal of Heart and Lung Transplantation podcast features the JHLT Digital Media Editors in round table talks with the Journal's contributors.
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Frequently Asked Questions
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