JHLT: The Podcast

Episode 90: The ASSIST CLAD Study: Using Mesenchymal Stromal Cells in New-Onset CLAD

August 19, 2026·11 min
Episode Description from the Publisher

In this episode, JHLT: The Podcast explores the study "The ASSIST CLAD study: A phase 2 randomized controlled trial of mesenchymal stromal cells for new-onset chronic lung allograft dysfunction," which appears in the August print issue of JHLT. Today's guest is Daniel C. Chambers, MBBS, MD, of The Prince Charles Hospital and Queensland Lung Transplant Service in Brisbane, Australia. From across the dateline, he and Digital Media Editor Erika Lease discuss: What inspired the team to explore the use of mesenchymal stromal cell (MSC) infusions in CLAD patients Preparation and treatment considerations for using MSCs How despite the negative outcome—the MSCs made no clear improvements in the patient groups—the study still pushes the field forward For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

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