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Healthier World with Quest Diagnostics: Daily Summaries Delivered
by Quest Diagnostics
Healthier World with Quest Diagnostics aims to prompt action from insight as we keep you up to date on current clinical and diagnostic topics to transform lives and illuminate a path to better health.
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- 5 days ago21 min
49 - Decoding minimal residual disease (22 mins)
Episode summary Minimal residual disease (MRD) testing is an emerging tool in precision oncology that can provide insights beyond traditional imaging and clinical assessment. In this episode, Rebecca Johnson Wheeler, MS, CGC, and Dr CK Wang explore how circulating tumor DNA (ctDNA) can be used to detect residual disease and discuss how MRD results may help inform recurrence risk, treatment response, and disease surveillance and explore the growing role of MRD testing in cancer care. This episode will Define minimal residual disease and describe how circulating tumor DNA (ctDNA) can be used to detect evidence of cancer that may remain after treatment Differentiate tumor-informed and tumor agnostic MRD approaches to testing, and what to consider when selecting an MRD test. Explain the clinical significance of MRD results and its clinical utility in muscle invasive bladder cancer care through a case example Recognize current and emerging clinical applications of MRD testing Date: November 2026 Speaker(s): Rebecca Johnson Wheeler, MS, CGC; CK Wang, MD Contributor(s): Rebecca Johnson Wheeler, MS, CGC; CK Wang, MD; Jared Snider, PhD; Mark Reed, PhD Additional resources: Quest Diagnostics Clinical Education Center Haystack MRD Ordering information: Contact to order Haystack MRD baseline References: National Comprehensive Cancer Network®. Bladder Cancer (Version 3.2026). Published August 2026. Accessed October 2, 2026. https://www.nccn.org Tie J, Wang Y, Lo SN, et al. Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial. Nat Med. 2025;31(5):1509-1518. doi:10.1038/s41591-025-03579-w Tie J, Cohen JD, Lahouel K, et al. Circulating tumor DNA Analysis guiding adjuvant therapy in stage II colon cancer. N Engl J Med. 2022;386(24):2261-2272. doi:10.1056/NEJMoa2200075 Powles T, Kann AG, Castellano D, et al. ctDNA-guided adjuvant atezolizumab in muscle-invasive bladder cancer. N Engl J Med. 2025;393(24):2395-2408. doi:10.1056/NEJMoa2511885 Zhou H, Zhu L, Song J, et al. Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer. Mol Cancer. 2022;21(1):86. doi:10.1186/s12943-022-01556-2
- 2 weeks ago21 min
48 - The cardiometabolic-dementia connection (21 min)
Cognitive decline is not an isolated brain disease but is deeply intertwined with systemic vascular and metabolic health. In this episode, Maeson Latsko, PhD, is joined by cardiologist Dr Marc Penn and neurologist Dr Michael Racke to break down the physiological links between cardiometabolic conditions and dementia. They discuss why primary care providers are the frontline defense in preventing cognitive decline, outlining a practical, 5-pillar diagnostic framework to identify at-risk patients. The conversation covers the clinical gaps in current screening, the utility of ruling out secondary causes of dementia, and how advanced Alzheimer's biomarkers can streamline specialist referrals and enable earlier intervention. This episode will Examine how cardiometabolic diseases like diabetes and hypertension contribute to neurodegeneration and cognitive decline Detail a 5-pillar framework for a comprehensive cognitive assessment that addresses nutritional, thyroid, inflammatory, metabolic, and circulatory health Discuss the role of advanced blood-based biomarkers for both identifying secondary causes of dementia and confirming Alzheimer's disease pathology Speakers: Maeson Latsko, PhD; Michael Racke, MD; Marc Penn, MD, PhD Contributors: Maeson Latsko, PhD; Michael Racke, MD; Marc Penn, MD, PhD; Natalie Cuttic; Kathryn Morales; Trisha Winchester, PhD, MBA; Millicent Kee, MSN, APRN, FNP-BC; Rebecca Johnson Wheeler, MS, CGC Ordering information Cognitive Assessment Panel AD-Detect™ ABeta 42/40 and p-tau217 Evaluation, Plasma Additional resources Podcast - Empowering primary care in the new era of Alzheimer’s disease diagnostics (25 min) Podcast - Instant insights: Blood-based biomarkers for Alzheimer’s Disease (8 min) Podcast - The Cardiometabolic approach: A solution to modern disease risk assessment (20 min) References Centers for Medicare & Medicaid Services. Cognitive assessment & care plan services. Medicare.gov. Accessed September 22, 2026. https://www.medicare.gov/coverage/cognitive-assessment-care-plan-services Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695-699. doi:10.1111/j.1532-5415.2005.53221.x Cummings J, Aisen P, Apostolova LG, Atri A, Salloway S, Weiner M. Aducanumab: appropriate use recommendations. J Prev Alzheimers Dis. 2021;8(4):398-410. doi:10.14283/jpad.2021.41 Jack CR Jr, Bennett DA, Blennow K, et al. NIA-AA Research Framework: toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018;14(4):535-562. doi:10.1016/j.jalz.2018.02.018 Gottesman RF, Stern Y, Provencio-Dean N, et al. The American Heart Association’s seven core metrics of cardiovascular health (Life’s Simple 7) and cognitive health. Stroke. 2017;48(5):1414-1421. doi:10.1161/STROKEAHA.116.015093 Atri A, Dickerson BC, Clevenger C, et al. Alzheimer's Association Clinical Practice Guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD-ADRD): executive summary of recommendations for primary care. Alzheimers Dement. 2025;21(6):e14333. doi:10.1002/alz.14333 Kramer ES, Johnson MN, Winslow B. Evaluation of suspected dementia. Am Fam Physician. 2025;112(6):657-667. Accessed September 29, 2026. https://www.aafp.org/afp/2025/1200/suspected-dementia-evaluation Galvin JE, Sadowsky CH; NINCDS-ADRDA. Practical guidelines for the recognition and diagnosis of dementia. J Am Board Fam Med. 2012;25(3):367-382. doi:10.3122/jabfm.2012.03.100181 Woodward M, Brodaty H, McCabe M, et al. Nationally Informed Recommendations on Approaching the Detection, Assessment, and Management of Mild Cognitive Impairment. J Alzheimers Dis. 2022;89(3):803-809. doi:10.3233/JAD-220288
- Oct 5, 202616 min
47 - Beyond BRCA: The bigger picture of hereditary breast cancer (17 mins)
Episode summary About 10% of breast cancers are hereditary, and about half of those are due to BRCA1 and BRCA2. In this episode, Rebecca Johnson Wheeler, MS, CGC, and Diana Tully, MS, CGC explore the broader genetic landscape of hereditary breast cancer, including the importance of looking beyond BRCA1 and BRCA2 in genetic testing. They’re joined by a breast cancer survivor whose multigene panel identified a CHEK2 variant, illuminating how that knowledge shaped her health journey despite having no family history of breast cancer. This episode will Differentiate hereditary from familial breast cancer Recognize personal and family history features that may indicate a hereditary cancer predisposition Describe the role of the genes beyond BRCA1 and BRCA2 in hereditary breast cancer and the value of comprehensive genetic testing Explain how identifying a hereditary cancer predisposition can inform cancer risk management and provide important information for family members Date: October 2026 Speaker(s): Rebecca Johnson Wheeler, MS, CGC; Diana Tully, MS, CGC, Kristen O’Hara Contributor(s): Rebecca Johnson Wheeler, MS, CGC; Diana Tully, MS, CGC; Kristen O’Hara; Kelly Tangney, MS, CGC; Marjan Champine, MBA, MS, CGC; Maeson Latsko, PhD Additional resources: Quest Diagnostics Clinical Education Center FORCE Ordering information: Quest Diagnostics Hereditary Cancer References: Apostolou P, Fostira F. Hereditary breast cancer: the era of new susceptibility genes. Biomed Res Int. 2013;2013:747318. doi:10.1155/2013/747318 National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic and Prostate (Version 1.2027). Published August 31, 2026. Accessed September 15, 2026. https://www.nccn.org Peleg Hasson S, Menes T, Sonnenblick A. Comparison of patient susceptibility genes across breast cancer: implications for prognosis and therapeutic outcomes. Pharmgenomics Pers Med. 2020;13:227-238. doi: 10.2147/PGPM.S233485 Wong ESY, Shekar S, Met-Domestici M, et al. Inherited breast cancer predisposition in Asians: Multigene panel testing outcomes from Singapore. npj Genomic Medicine. 2016;1(1). doi:10.1038/npjgenmed.2015.3 Hanson H, Pal T, Tischkowitz M, et al. CHEK2-related cancer predisposition.. In: Adam MP, Bick S, Mirzaa GM, et al., editors. GeneReviews®. University of Washington, Seattle; March 25, 2026. Accessed September 15, 2026. https://www.ncbi.nlm.nih.gov/books/NBK615090/
- Sep 21, 202623 min
46 - New frontiers in PCOS management (23 min)
Polycystic Ovarian Syndrome (PCOS) is a common hormonal and metabolic disorder affecting millions of women, yet a staggering number of cases go undiagnosed. Now, a proposed name change and new diagnostic tools are set to redefine how this complex condition is managed. In this episode, Maeson Latsko, PhD is joined by Marco Marcelli, MD, a board-certified endocrinologist and Medical Director in Research and Development at Quest Diagnostics. They explore the clinical shift toward recognizing PCOS as a metabolic condition, the evolution of diagnostic standards from the Rotterdam criteria to new international guidelines, the pivotal role of AMH blood testing as a noninvasive alternative to ultrasound, and what emerging global data reveals about the true prevalence and presentation of the syndrome. This episode will Discuss the clinical reasoning behind the proposed name change from Polycystic Ovarian Syndrome (PCOS) to Polyendocrine Metabolic Ovarian Syndrome (PMOS) and its implications for managing the condition Review the evolution of diagnostic criteria, from the 2003 Rotterdam consensus to the 2023 international guidelines that established Anti-Müllerian Hormone (AMH) as a non-invasive alternative to ultrasound Explore emerging global data on the prevalence and phenotypic expression of PCOS, highlighting significant variations across diverse ethnic populations and the impact of cultural practices on diagnosis Describe the clinical significance and approach for patients who present with isolated polycystic ovarian morphology (PCOM) on an ultrasound but lack other traditional symptoms of PCOS Speakers: Marco Marcelli, MD; Maeson Latsko, PhD Contributors: Maeson Latsko, PhD; Marco Marcelli, MD; Gregory Buchan, PhD; Trisha Winchester, PhD, MBA; Abhi Patel; Sanjay Dixit, MD; Millicent Kee, MSN, APRN, FNP-BC Ordering information Hyperandrogenism: Testosterone, Free (Dialysis) and Total, MS Hyperandrogenism: Testosterone, Free (Dialysis), Total (MS) and Sex Hormone Binding Globulin PCOM: Anti-Mullerian Hormone (AMH), Female Thyroid disease: TSH Congenital adrenal hyperplasia: 17-Hydroxyprogesterone Hyperprolactinemia: Prolactin Additional resources PCOS Test Guide Quest Diagnostics Polycystic ovary syndrome Clinical Focus: Polycystic Ovary Syndrome Polycystic Ovary Syndrome (PCOS) Diagnostic Algorithm Laboratory Testing in the Differential Diagnosis of PCOS and NCCAH Podcast: Laboratory assessment in PCOS diagnosis and management References Naeem I, Zehra A, Rehman F, et al. Polycystic ovarian syndrome a risk factor for non-communicable diseases: insights into recent research and prevention approaches. J Ovarian Res. 2025;18(1):219. doi:10.1186/s13048-025-01741-z Teede HJ, Tay CT, Laven JJE, et al. Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2023;108(10):2447-2469. doi:10.1210/clinem/dgad463 Teede HJ, Khomami MB, Morman R, et al. Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process. Lancet. 2026;407(10545):2329-2339. doi:10.1016/S0140-6736(26)00717-8 Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to
- Sep 8, 202622 min
45 - The evolving role of comprehensive genomic profiling and liquid biopsy in oncology care (22 min)
As the number of clinically relevant cancer biomarkers and targeted therapies continues to grow, comprehensive genomic profiling and liquid biopsy are playing an increasingly important role in precision oncology. In this episode, Rebecca Johnson Wheeler, MS, CGC, and Dr Harmeet Dhani explore how biomarker testing has evolved, the complementary roles of tissue and liquid biopsy, and how advances in testing are helping to identify the right care for the right patient across the cancer care continuum. This episode will Describe the pros and cons of tissue and blood-based comprehensive genomic profiling technologies and how they complement each other Discuss the relevant guidelines for precision oncology and how providers and laboratories integrate them into practice Explore balancing comprehensive molecular information and clinical actionability and opportunities to reduce delays Review a patient case where comprehensive genomic profiling influenced care Date: September 2026 Speaker(s): Rebecca Johnson Wheeler, MS, CGC; Harmeet Dhani, MD, MBA Contributor(s): Rebecca Johnson Wheeler, MS, CGC; Harmeet Dhani, MD, MBA; Anjana Bhattacharya, PhD; Maeson Latsko, PhD; Lawrence Bai, PhD; Mark Reed, PhD; Marjan Champine, MS, MBA, CGC Additional resources: Quest Diagnostics Clinical Education Center Quest Diagnostics Solid Tumor Quest Diagnostics Oncology Solid Tumor Identifying Genetic Drivers White Paper Ordering information: Quest Diagnostics Precision Oncology Menu Oncology Test Requisition Oncology portal References: Sheikholeslami S, Loo EY. AMP case report: Ultra-hypermutated colorectal adenocarcinoma identified at relapse. CAP TODAY. June 2026 Aghamir SMK, Heshmat R, Ebrahimi M, et al. Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors. Epigenet Insights. 2020;13:2516865720904052. Published 2020 Feb 28. doi:10.1177/2516865720904052 National Comprehensive Cancer Network. Non-Small Cell Lung Cancer (Version 7.2026). Published June 2026. Accessed August 2, 2026. https://www.nccn.org National Comprehensive Cancer Network. Pancreatic Adenocarcinoma (Version 3.2026). Published June 2026. Accessed August 2, 2026. https://www.nccn.org Wallenta Law J, Bapat B, Sweetnam C, et al. Real-World Impact of Comprehensive Genomic Profiling on Biomarker Detection, Receipt of Therapy, and Clinical Outcomes in Advanced Non-Small Cell Lung Cancer. JCO Precis Oncol. 2024;8:e2400075. doi:10.1200/PO.24.00075 Lockwood CM, Messersmith HJ, Kim AS, et al. Circulating Tumor DNA Testing in Solid Tumors and Lymphoma: ASCO Guideline. JCO Oncol Pract.; June 18, 2026. Accessed August 2, 2026. https://ascopubs.org/doi/10.1200/OP-26-00311 Pankiw M, Brezden-Masley C, Charames GS. Comprehensive genomic profiling for oncological advancements by precision medicine. Med Oncol. 2023;41(1):1. Published 2023 Nov 22. doi:10.1007/s12032-023-02228-x
- Aug 24, 202616 min
44 - Navigating the modern patient journey in HIV care (16 min)
While HIV has transitioned from an acute, life-threatening infection to a highly manageable chronic condition, significant complexities in screening, prevention, and long-term care remain. In this episode, Maeson Latsko, PhD, discusses the dramatic evolution of HIV care with Dr Ann MacIntyre, DO, a board-certified infectious disease physician and Senior Medical Director of Infectious Disease at Quest Diagnostics. They explore the cellular mechanisms of HIV, the timeline of diagnostic markers in the blood, the vital role of PrEP and baseline testing, and the clinical shift toward holistic, longitudinal care for patients aging with the virus. This episode will Explain the cellular mechanism of HIV infection and map the clinical timeline of diagnostic markers in the blood, including viral RNA, p24 antigen, and antibodies Differentiate between historic and modern HIV testing methodologies, highlighting how the fourth-generation antigen/antibody combo assay addresses the critical window period Outline the comprehensive laboratory testing required for safe PrEP initiation, including screening for co-infections like Hepatitis B and monitoring metabolic markers Analyze clinical strategies for staging newly diagnosed patients and managing long-term viral suppression, addressing the complex systemic impacts of chronic inflammation on aging patients Speakers: Dr Ann MacIntyre, DO; Maeson Latsko, PhD Contributors: Maeson Latsko, PhD; Dr Ann MacIntyre, DO; Katherine Watson; Trisha Winchester, PhD; Frank Samarro Ordering information HIV-1/2 Antigen and Antibodies, Fourth Generation, with Reflexes | Test Detail | Quest Diagnostics HIV-1/2 Antigen and Antibodies, Fourth Generation, with Reflexes | Test Detail | Quest Diagnostics HIV-1 RNA, Quantitative, Real-Time PCR | Test Detail | Quest Diagnostics HIV-1 RNA, Quantitative, Real-Time PCR | Test Detail | Quest Diagnostics HIV-1 RNA, Quantitative, PCR with Reflex to Genotype | Test Detail | Quest Diagnostics HIV-1 RNA, Quantitative, PCR with Reflex to Genotype | Test Detail | Quest Diagnostics Additional resources Clinical Education Center | Quest Diagnostics Clinical Education Center | Quest Diagnostics HIV testing | Quest Diagnostics HIV testing | Quest Diagnostics References US Preventive Services Task Force. Screening for HIV Infection: US Preventive Services Task Force Recommendation Statement. JAMA. 2019;321(23):2326-2337. doi:10.1001/jama.2019.6587 Centers for Disease Control and Prevention and Association of Public Health Laboratories. Laboratory Testing for the Diagnosis of HIV Infection: Updated Recommendations. CDC. 2014. CDC. HIV treatment and care. Updated April 16, 2026. Accessed August 6, 2026. https://www.cdc.gov/hiv/clinicians/treatment-care/index.htmlClinical Care of HIV | HIV Nexus | CDC CDC. Clinical Guidance for PrEP | HIV Nexus | CDC. Updated April 30, 2026. Accessed August 6, 2026. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Department of Health and Human Services. Updated May 27, 2026. Available at https://clinicalinfo.hiv.gov/en/guidelines/adult-and-adolescent-arv. Accessed August 6, 2026.
- Aug 3, 202622 min
43 - Empowering patients through HPV self-collection (22 min)
Despite cervical cancer being one of the most preventable cancers, significant gaps in screening still leave many people vulnerable. But what if the screening process could be brought directly to the patient on their own terms? In this episode, Maeson Latsko, PhD, discusses the ongoing evolution of cervical cancer screening with Quest Diagnostics experts Megan Starolis, MS, PhD, HCLD(ABB), a Senior Scientific Director in Infectious Disease, and Damian Alagia, MD, MS, MBA, the Senior Medical Director for Advanced Diagnostics in Women's Health. They explore the science behind HPV DNA and mRNA testing, the clinical considerations for different screening algorithms, and the revolutionary potential of patient self-collection to improve health equity and save lives. This episode will Trace the evolution of cervical cancer screening from the Pap smear to modern molecular testing and self-collection, and recognize its potential to improve access to care Differentiate between HPV DNA and mRNA testing methodologies and analyze the clinical benefits and considerations for primary screening vs co-testing algorithms Explore how HPV self-collection can break down barriers to care for underserved populations and improve health equity Recognize the critical importance of ensuring appropriate patient follow-up to complete the care continuum after a positive self-collected test Speakers: Dr Megan Starolis, MS, PhD, HCLD(ABB); Dr Damian Alagia, MD, MS, MBA; Maeson Latsko, PhD Contributors: Maeson Latsko, PhD; Dr Megan Starolis, MS, PhD, HCLD(ABB); Dr Damian Alagia, MD, MS, MBA Ordering information HPV Self-Collection HPV DNA (16, 18, Other High Risk), PCR, Vaginal Self-Collected | Test Detail | Quest Diagnostics Additional resources Clinical Education Center | Quest Diagnostics Instant insights: HPV testing for cervical cancer screening| Healthier World with Quest Diagnostics Bringing cervical cancer screening closer to patients | Quest Diagnostics Reference List Screening for Cervical Cancer. Obstetrics & Gynecology. 2026;148(1):e63-e67. doi:10.1097/AOG.0000000000006257
- Jul 27, 202618 min
42 - Primary aldosteronism insights from a nephrologist (18 min)
Up to 30% of hypertensive patients in specialty care settings may have underlying Primary Aldosteronism (PA), yet a massive diagnostic gap still exists in screening for PA. In this episode, Maeson Latsko, PhD, and Jeffrey Hymes, MD, discuss the critical intersection of resistant hypertension, chronic kidney disease (CKD), and PA. They shed light on the direct, blood-pressure-independent toxicity of excess aldosterone on the kidneys and unpack the latest clinical guidelines from the AHA/ACC and Endocrine Society. They also review a guideline-based algorithm designed to streamline screening and follow-up for PA evaluation. This episode will Explore the bidirectional relationship between chronic kidney disease (CKD) and hypertension, recognizing Primary Aldosteronism (PA) as a highly prevalent underlying cause Detail the direct toxicities of excess aldosterone, independent of systemic blood pressure Review updated clinical guidelines and a practical diagnostic algorithm to screen, triage, and manage PA patients Ordering information Kidney Profile Kidney Profile with reflex to eGFR (Creatinine-Cystatin C) Kidney Profile with eGFR (Creatinine-Cystatin C) eGFR (Creatinine-Cystatin C) Plasma Renin Activity with Reflex to Aldosterone Additional resources Clinical Education Center | Quest Diagnostics Interpretation of Plasma Renin Activity With Reflex to Aldosterone Test (test code 13817) | Algorithm | Quest Diagnostics Primary aldosteronism algorithm brochure Quest Diagnostics nephrology brochure Primary aldosterone landing page Hypertension insights landing page Reference List Whelton PK, Carey RM, Aronow WS, et al. 2025 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2025;85(4):e123-e145. Funder JW, Carey RM, Mantero F, et al. The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(5):1889-1916. doi:10.1210/jc.2015-4061 Adler GK, Stowasser M, Correa RR, et al. Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2025;110(9):2453-2495. doi:10.1210/clinem/dgaf284 Brown JM, Siddiqui M, Calhoun DA, et al. The unrecognized prevalence of primary aldosteronism: a cross-sectional study. Ann Intern Med. 2020;173(1):10-20. doi:10.7326/M20-0065 Centers for Disease Control and Prevention. Risk Factors for Chronic Kidney Disease. Centers for Disease Control and Prevention. Updated May 15, 2024. Accessed July 13, 2026. https://www.cdc.gov/kidney-disease/risk-factors/index.html
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