Mailbag: Why GLP-1 Medications Sometimes Stop Working

Have you been told your metabolism is broken and there's nothing you can do about it?This mailbag episode tackles tough questions about medication effectiveness, unexpected side effects, and the complex realities of treating metabolic dysfunction. Dr. Cooper addresses why some people regain weight while still on GLP-1s, explores the connection between hair loss and weight loss medications, and explains why leptin levels can remain stubbornly low even with proper nutrition.KEY TAKEAWAYSWeight regain while on GLP-1 medications is more common than most people realizeHair loss from weight loss medications is usually related to nutrient deficiencies, not the medication itselfLeptin dysfunction involves both hormone levels and signaling pathways throughout the bodyHypoglycemia after meals often indicates complex metabolic issues that require specialized testingStarting elderly patients on GLP-1s requires careful monitoring of nutrition, blood pressure, and side effectsMechanical eating differs from intuitive eating and remains important even when medications are workingAnnual weight loss rates of 10% or higher indicate medications are still effectiveNOTABLE QUOTE"It is not uncommon to see the weight go up while on these meds, contrary to what people think. They're great, but we always wanna point out some people don't even respond to these." — Dr. Emily CooperLinks & ResourcesPodcast Home: fatsciencepodcast.comCooper Center for Metabolism: coopermetabolic.comResources from Dr. Cooper: coopermetabolic.com/resourcesJoin Our Community: patreon.com/cw/FatSciencePodcastSubmit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.comFat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.