Tiny Matters

Giant viruses: How these amoeba-infecting behemoths are rewriting the rules of virology

August 19, 2026·36 min
Episode Description from the Publisher

Scientists spent decades searching for viruses by filtering out anything too large to be one. That strategy seemed to work well... until it didn't. When researchers discovered a microbe living inside an amoeba that looked like a bacterium but behaved like something else entirely, they uncovered a hidden world of giant viruses with massive genomes, unusual genes, and even their own viral parasites. In this episode, we dive into the discoveries that forced scientists to rethink what viruses are, how they evolve, and whether the rules historically used to define them still hold up.Check out Dreaming Against the Machine here or wherever you listen to podcasts!A transcript and references for this episode can be found at acs.org/tinymatters.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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