Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94

A gene mutation that reduces ketone production in the fasted state is associated with sudden infant death in modern populations. But in the ancestral context where it evolved alongside an omega-3-rich diet, it may have been part of what kept infants alive. Dr. Gideon Mailer and Nicola Hale join The Metabolic Link to present their hypothesis that the CPT1A L479 Arctic variant is not anti-ketogenic but pro-metabolic flexibility, conserving glucose by upregulating ketosis at the fed-state thresh...