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The Metabolic Link: Daily Summaries Delivered
by Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field
Welcome to The Metabolic Link, a medical and science podcast that explores the common thread of metabolism in health and disease. Join Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field as they dive into the latest research on metabolic health and therapy alongside some of the world’s leading experts. They'll also discuss how this science is being applied in the real world. This is where science meets society.
Latest Episodes
The most recent episodes — sign up to get AI-powered summaries of each one.
- 2 days ago1h 6m
Ben Bikman, PhD | Rethinking Metabolic Health: Insulin, Ketones, and What Comes Next | The Metabolic Link Ep. 100
For the 100th episode of The Metabolic Link, Ben Bikman, PhD, professor of cell biology and physiology at Brigham Young University and author of Why We Get Sick, returns for a milestone conversation with co-hosts Dominic D’Agostino, PhD, and Victoria Field. Together, they examine what clinicians are measuring, what conventional approaches may be missing, and how the science of metabolic health continues to evolve. Bikman argues that the clinical picture of metabolic health remains glucose-ce...
- 2 weeks ago1h 8m
Type 1 Diabetes on a Ketogenic Diet: What a 1,000-Mile Bike Ride Revealed | Dr. Ian Lake | The Metabolic Link Ep. 99
What can 21 days of continuous glucose and ketone data, recorded during a 1,000-mile cycling journey, reveal about managing type 1 diabetes on a ketogenic diet? Dr. Ian Lake is a UK-based primary care physician who has lived with type 1 diabetes for more than 30 years. After two decades of conventional high-carbohydrate management, he adopted a very low-carbohydrate, ketogenic approach and began examining insulin not simply as a glucose-lowering medication, but as a metabolic hormone whose re...
- Jun 30, 20261h 5m
Ozempic, Insulin Resistance, and Type 2 Diabetes: What Are We Missing? | Dr. Mariela Glandt | The Metabolic Link Ep. 98
Attend a Live Q&A with Dr. Glandt. Reigster here. What if the way we treat type 2 diabetes is fundamentally backwards? Dr. Mariela Glandt is an endocrinologist and obesity medicine specialist who spent 15 years practicing conventional medicine before concluding, in her words, that how we treat diabetes “is actually upside down.” As co-founder of OwnaHealth, she focuses on addressing the insulin resistance underlying type 2 diabetes, not only the elevated blood sugar it eventually causes. ...
- Jun 16, 20261h 17m
Treating PTSD When Standard Care Falls Short: A Hyperbaric Oxygen Protocol | Dr. Keren Doenyas-Barak, MD | The Metabolic Link Ep. 97
Fewer than 40% of people with PTSD respond to standard care. For the intrusive symptoms at the core of the disorder, response rates may be lower than 15%. So what options remain for patients who have not responded to existing treatments? Dr. Keren Doenyas-Barak, director of the PTSD program at the Sagol Center for Hyperbaric Medicine and Research and a faculty member at Tel Aviv University, has treated close to 1,000 civilian and military patients and led sham-controlled trials that are helpi...
- Jun 2, 20261h 14m
Inflammation and Glycation: The Two Heads of Chronic Disease | Dr. Paul Reynolds, PhD | The Metabolic Link Ep. 96
Dr. Paul Reynolds has spent his career studying what he calls “two heads of the same beast”: inflammation and glycation — two interlocking processes that may help explain why so many chronic diseases are connected, even when they are treated as separate conditions. Dr. Reynolds is a professor and research scientist at Brigham Young University whose NIH-funded research program studies inflammation, lung biology, glycation, and the AGE/RAGE receptor system that links metabolic and environmental...
- May 19, 202651 min
Metabolic Psychiatry in Clinical Practice: Brain Energy, Common Pitfalls, & Precision Nutrition | Dr. Bret Scher, MD | The Metabolic Link Ep. 95
In people with severe depression and cognitive decline, brain glucose metabolism has been shown in some studies to decline measurably. Ketone metabolism, by contrast, appears relatively preserved. That single observation is reshaping how researchers think about psychiatric illness. In this episode, Dominic D'Agostino sits down with Bret Scher, a cardiologist who pivoted to metabolic psychiatry and now leads clinical education and content for Metabolic Mind at the Baszucki Group. Dr. Scher bri...
- May 5, 20261h 26m
Inuit Metabolism Revisited: Ketosis, Omega-3s, & the CPT1A Arctic Variant | Dr. Gideon Mailer & Nicola Hale | The Metabolic Link Ep. 94
A gene mutation that reduces ketone production in the fasted state is associated with sudden infant death in modern populations. But in the ancestral context where it evolved alongside an omega-3-rich diet, it may have been part of what kept infants alive. Dr. Gideon Mailer and Nicola Hale join The Metabolic Link to present their hypothesis that the CPT1A L479 Arctic variant is not anti-ketogenic but pro-metabolic flexibility, conserving glucose by upregulating ketosis at the fed-state thresh...
- Apr 21, 20261h 24m
Understanding Female Metabolism: PCOS, Postpartum, and Menopause | Madison Kackley, PhD | The Metabolic Link
In a 12-week clinical trial at The Ohio State University, every woman with PCOS who completed the intervention experienced a change in her menstrual status. One participant, who had never had a period in her life, began menstruating within a week. Another saw spotting after five years of amenorrhea while taking only a ketone supplement without adopting a ketogenic diet. These are among the earliest controlled findings linking ketogenic interventions directly to reproductive hormone restoratio...
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About The Metabolic Link
Welcome to The Metabolic Link, a medical and science podcast that explores the common thread of metabolism in health and disease. Join Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field as they dive into the latest research on metabolic health and therapy alongside some of the world’s leading experts. They'll also discuss how this science is being applied in the real world. This is where science meets society.
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Frequently Asked Questions
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It's a free AI-powered email that summarizes new episodes of The Metabolic Link as soon as they're published. You get the key takeaways, notable quotes, and links & mentions — all in a quick read.
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How often does The Metabolic Link release new episodes?
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The Metabolic Link covers topics including Medicine, Fitness, Health & Fitness. Our AI identifies the specific themes in each episode and highlights what matters most to you.
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