The Longevity & Lifestyle Podcast

#249 Dr. Momchilo Vuyisich — How Your Microbiome Controls Immunity, Chronic Disease & Longevity

May 15, 2026·52 min
Episode Description from the Publisher

What if your microbiome is influencing far more than digestion - from your brain and immune system to aging, energy and chronic disease risk?In this fascinating episode, Dr. Momchil “Momo” Vuyisich joins Claudia to unpack the science of the microbiome, microbial function and personalized nutrition.We explore:• Why Your Gut Microbiome Shapes Human Health • The Difference Between Microbes and Microbial Function • How Gut Bacteria Influence Brain Health and Cognition • Why Antibiotic Overuse May Increase Chronic Disease Risk • The Role of Fermented Foods and Probiotics • Why Personalized Nutrition Is the Future of Healthcare • The Importance of Keystone Species Like Akkermansia • How Food Preservatives and Modern Diets Affect the Gut • Why Testing and Data Create Actionable Health Insights • The Future of Microbiome Science and Precision HealthThis conversation is a powerful reminder that longevity starts with understanding the invisible ecosystem living inside us.Timestamps 00:00 - Why chronic stress may be destroying your body 00:38 - Dr. Momchilo Vuyisich’s background and work at Viome 01:33 - Why humans are an ecosystem, not just an individual 03:58 - Why fiber is essential for feeding the microbiome 04:52 - How the microbiome is shaped at birth 06:31 - Why asthma, food allergies, and IBD may be rising 08:13 - How mothers can support a healthier microbiome before pregnancy 09:40 - The hidden long-term cost of antibiotics 11:06 - How preservatives and non-organic meat may harm the microbiome 12:22 - How to rewild your microbiome after disruption 16:46 - Why some keystone strains are so hard to restore 18:19 - Microbial function vs. microbial strains 20:49 - How microbial metabolites affect the brain and body 24:25 - Why personalized nutrition may matter more than generic healthy eating 27:20 - The four pillars of health: food, exercise, Zen, and sleep 29:58 - Why there is no single optimal diet for everyone 32:34 - Minimum effective exercise for longevity 34:21 - Why stress management is non-negotiable 37:48 - Why sleep sets up your entire next day 39:33 - Are naps helpful or harmful? 40:22 - The microbiome and neurodivergence 43:07 - Can chronic disease become preventable? 44:31 - Preventive maintenance for the human body 46:34 - How the microbiome may influence immune memory 48:13 - What Dr. Vuyisich is building at Viome now 51:15 - Where to follow Dr. Vuyisich and learn moreSubscribe to Longevity & Lifestyle for science-backed insights on longevity, health optimization, brain health, metabolic health, women’s health, and performance.#microbiome #guthealth #longevity #healthoptimization #immunity #brainhealth #metabolichealth #personalizednutrition #biohacking #healthyaging

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