The Integrative Health Podcast with Dr. Jen

Why Mast Cells Keep You Stuck in Fight or Flight

September 8, 2026·23 min
Episode Description from the Publisher

If you have mast cell symptoms and constantly feel stuck in fight or flight, the connection may be more physical than you realize. In Part 2 of this three-part solo series, Dr. Jen explains how mast cells and the nervous system communicate with each other, creating a feedback loop that can drive histamine release, anxiety, poor sleep, palpitations, hypervigilance, inflammation, and increased sensitivity to everyday triggers. She breaks down how stress signaling through CRH and the autonomic n...

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