Why Perimenopause Can Trigger Histamine Problems

Why do some women suddenly react to wine, leftovers, fermented foods, heat, supplements, or even medications they used to tolerate? In Part 3 of this solo mast cell series, Dr. Jen explains how shifting hormones in perimenopause can lower the threshold for histamine reactions and mast cell activation. She breaks down how estrogen may increase mast cell reactivity, why declining progesterone can reduce some of the body’s calming support, and how poor sleep, stress, cortisol, mold exposure, gut...