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The Human Upgrade: Biohacking for Longevity & Performance: Daily Summaries Delivered
by Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.
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- Yesterday1h 7m
The Truth About Vitamins, Supplements & Prescription Drugs | Phil Cowley : 1567
Triquetra Discount: Use code Dave20 at Triquetrahealth.com/dave Multivitamin Mistakes, MTHFR Genetics, B Vitamins, Creatine & Prescription Drug Risks Host Dave Asprey sits down with Phil Cowley, a pharmacist, founder of Cache Valley Pharmacy, and creator of Phil's My Pharmacist, to explore multivitamins, prescription medications, supplement effectiveness, MTHFR genetics, methylated B vitamins, creatine, and the hidden problems within modern healthcare. After opening his pharmacy in Logan, Utah, in 2001, Phil spent two decades serving patients and dispensing millions of prescriptions. By 2021, declining insurance reimbursements threatened his business despite increasing prescription volume. He turned to social media to share practical, affordable health advice, eventually building an audience of more than six million followers. Now, he explains what his experience behind the pharmacy counter taught him about medication side effects, nutritional deficiencies, supplement quality, and why conventional healthcare often overlooks individual biology. The conversation examines common multivitamin mistakes, including the use of synthetic folic acid and pyridoxine (vitamin B6). Phil explains why certain nutrient forms may be less suitable for some individuals, how excessive B6 intake can cause peripheral neuropathy, and why buying more supplements doesn't necessarily improve health. They explore MTHFR genetic variants, methylation, and folate metabolism, including potential implications for cognitive function, inflammation, blood pressure, fertility, and neurological development. Phil also reveals why creatine is his favorite supplement, discussing its potential benefits for brain health and muscle performance. He and Dave examine creatine dosing, hydration, electrolytes, absorption, and why creatine supplementation can influence kidney-related blood test results. The discussion turns to Big Pharma, prescription drug pricing, and pharmacy benefit managers (PBMs). Phil shares how insurance reimbursement practices threatened his independent pharmacy despite increasing prescription volume. They also explore compounding pharmacies, customized hormone formulations, injectable vitamins, GLP-1 medications, and the challenges of providing personalized treatment within the conventional healthcare system. Finally, Dave and Phil examine personalized medicine, genetic testing, medication interactions, and nutritional deficiencies, including the relationship between statins and CoQ10. They discuss why individual biology should guide supplement choices and how addressing underlying metabolic processes may offer a more comprehensive approach to long-term health. This episode is essential listening for anyone interested in multivitamins, methylated B vitamins, MTHFR genetics, creatine, prescription drugs, supplement effectiveness, personalized nutrition, metabolic health, and longevity. You'll Learn: Why common multivitamins contain different forms of B vitamins, and how folic acid, folinic acid, L-methylfolate, and P5P differ How MTHFR genetic variants influence folate metabolism and why individual responses to supplements can vary What Phil recommends considering when using creatine for brain health, muscle performance, hydration, and kidney-related blood testing How pharmacy benefit managers, insurance reimbursement, and drug pricing affect independent pharmacies and patient care Why compounding pharmacies create customized medications, including hormone formulations, injectable vitamins, and certain GLP-1 treatments How personalized supplementation, nutrient testing, medication interactions, and genetics may help inform more individualized healthcare decisions Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New e
- 3 days ago38 min
I Tried EVERY Controversial Focus Drug : 1566
I've tried every controversial focus drug I could get my hands on. Modafinil, LSD, psilocybin, mescaline, DMT, ketamine, MDMA, amphetamine, ephedrine, the racetams, and a shelf of Russian compounds most people have never heard of. I've spent 20 years and millions of dollars testing this on my own brain, and here's what I found: some of them work, most don't do what you've been told, and none of them are free.But the one I'd crown above all of them is legal, costs almost nothing, and you can buy it this afternoon. You've just been lied to about it for 60 years by the people who made a fortune doing it. In this video I'll show you what each compound actually does inside your brain, what it takes from you on the other side, and the four rules I follow so the best one doesn't turn into the worst one.You'll Learn:Why modafinil is considered the closest thing to a "Limitless pill" and how it affects sleepHow LSD, psilocybin, MDMA, and ketamine affect the brain differently from focus drugsWhy Adderall and amphetamines can make you hyper-focused on the wrong thingsHow racetams became the original nootropics for cognitive enhancementWhat Russian scientists developed for cosmonauts and soldiers, including bromantane, Semax, and SelankWhy pharmaceutical nicotine ranks among the most controversial focus enhancersHow nicotine affects acetylcholine, attention, memory, and potentially brain agingWhy nicotine and smoking have very different health risksHow delivery speed influences addiction risk, from cigarettes to patches and lozengesDave's four rules for reducing nicotine risks and who should avoid itWhat Dave learned from spending $2.5 million experimenting with cognitive enhancementTimestamps:00:00 - Trailer01:07 - Modafinil: The Limitless Pill03:45 - Psychedelics vs. Focus Drugs05:31 - Microdosing & The Placebo Effect07:43 - Cocaine & Drug Tolerance08:33 - Amphetamines & Adderall17:09 - Racetams: The Original Nootropics21:12 - Russian Smart Drugs29:17 - Nicotine for Focus & Cognition33:53 - Nicotine Risks & Safety RulesThank you to our sponsors!-Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.-ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.-Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit Simplify.us/NestEgg to learn more.-Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Join my Substack: https://substack.daveasprey.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
- 5 days ago10 min
Placebo Pills, Cannabis, Wall Squats for Blood Pressure, Birdwatching, and the Porn brain : 1564
Placebos Improved IBS Symptoms Even When Patients Knew the Pills Were InactiveIn a randomized trial of 80 adults with irritable bowel syndrome, participants who knowingly took placebo pills reported greater symptom improvement than those receiving no treatment. After three weeks, 59% of the placebo group reported adequate relief compared with 35% of controls. A larger follow-up study also found that openly prescribed placebos improved reported IBS symptoms more than a no-pill control. Host Dave Asprey explores how conditioning, expectations, and the ritual of taking a treatment may influence symptoms without deception. He explains why these findings do not mean symptoms are imaginary or that positive thinking can cure disease, but raise questions about how the brain, treatment context, and learned physiological responses shape the experience of illness.Sources:PLOS ONE: Placebos Without Deception—A Randomized Controlled Trial in Irritable Bowel SyndromePain: Open-Label Placebo vs. Double-Blind Placebo for Irritable Bowel SyndromeHarvard Health: A Placebo Can Work Even When You Know It’s a PlaceboOnce-Weekly Wall Squats Preserved Some Blood-Pressure Benefits After More Frequent TrainingA randomized trial involving 100 adults found that isometric wall-squat training reduced blood pressure, with some benefits maintained after participants cut back to one or two sessions per week. The important detail is that participants first completed four weeks of training three times weekly. Those who subsequently reduced to one weekly session finished the eight-week study with systolic blood pressure approximately 6.6 mmHg below baseline, while those continuing three weekly sessions experienced the largest improvement. Host Dave Asprey explores how sustained muscle contractions may influence vascular resistance and autonomic regulation, and why the minimum dose needed to maintain a benefit can differ from the dose needed to build it. He explains why this study does not show that beginners get the same results from one weekly session or that wall squats replace medication.Sources:BMJ Open Sport & Exercise Medicine: Isometric Exercise Training and Blood Pressure ControlFull Study: Exploring the Dose-Response to Training FrequencyExpert Birdwatchers Showed Brain Differences Linked to Attention and PerceptionA study comparing 29 expert birdwatchers with 29 beginners found differences in brain structure and activity associated with bird-identification expertise. Experts showed lower mean diffusivity in regions involved in attention and perception, an MRI finding researchers interpreted as more compact tissue organization. Some differences were also present in older experts, raising questions about how sustained learning may relate to cognitive aging. Host Dave Asprey examines why birdwatching involves more than spending time outdoors: identifying unfamiliar species requires attention, visual discrimination, memory, and continued learning. He explains why these findings are interesting without proving that birdwatching prevents dementia or slows cognitive decline, since researchers cannot determine whether the hobby caused the differences or whether preexisting characteristics helped people become experts.Sources:The Journal of Neuroscience: The Tuned Cortex—Expertise-Related Structural and Functional Remodeling Across the Adult LifespanSociety for Neuroscience: Skills From Being a Birder May Change—and Benefit—Your BrainBBC Future: Birdwatching Rewires the Brain and Slows Cognitive DeclineEarly THC Exposure Changed Serotonin Signaling in Mice Through an mTOR-Related PathwayA mouse study found that chronic THC exposure beginning early in life altered signaling through serotonin 5-HT2A receptors and increased sen
- 6 days ago51 min
The No-Brainer Solution To Stop Overeating : 1565
Use Dave10 at calocurb.com to get a discount How Hops Extract Suppresses Hunger, Reduces Cravings, Supports Weight Loss, and Makes Intermittent Fasting EasierHost Dave Asprey sits down with Sarah Kennedy, CEO of Calocurb, to explore the surprising science of hunger suppression, natural GLP-1 activation, intermittent fasting, weight loss, visceral fat reduction, and a patented hops extract that may help people eat less without relying on willpower. The conversation centers on Amarasate, a natural compound derived from New Zealand hops, the same plant used to make beer. Originally investigated through a multimillion-dollar research program, this bitter plant extract activates specialized receptors in the digestive tract that stimulate the body's natural appetite-regulating hormones. Sarah explains how this discovery led to Calocurb, a supplement designed to reduce hunger, control cravings, and make fasting and calorie restriction easier. Dave and Sarah break down the biology of GLP-1, CCK, PYY, ghrelin, and leptin, exploring how these hormones influence hunger, fullness, food cravings, and metabolic health. Unlike injectable GLP-1 medications such as Ozempic and Wegovy, Amarasate works through bitter taste receptors in the gut to stimulate the body's own satiety signaling. They examine why the timing and location of these signals matter, how quickly the extract begins working, and what distinguishes this approach from conventional appetite suppressants. Sarah shares findings from four human clinical trials, including research reporting an average 18% reduction in calorie intake following consumption of the hops extract. They discuss how activating gut receptors can influence eating behavior, why some people struggle with persistent hunger despite consuming enough calories, and how manipulating the body's natural fullness signals could change approaches to weight management. The discussion also examines a six-month randomized, placebo-controlled study involving approximately 150 participants, which reported an average 5.5% reduction in body weight, with estimated fat loss and no detected average muscle loss. Sarah describes findings suggesting approximately 3.5 times greater visceral fat reduction compared with placebo, raising questions about whether targeted appetite regulation could support healthier body composition. Dave and Sarah explore why preserving lean muscle while reducing abdominal fat is especially important for metabolic health, healthy aging, and longevity. They also explore how hops extract may make intermittent fasting and extended fasting easier by reducing hunger and food cravings. Dave discusses the practical challenges of fasting, while Sarah explains how bitter receptor activation can help people manage appetite without constantly fighting the urge to eat. They examine the potential applications for time-restricted eating, longer fasting windows, calorie control, and sustainable weight management. Finally, Dave and Sarah challenge conventional assumptions about willpower, hunger, and obesity, exploring why overeating is not simply a failure of discipline. They discuss the relationship between gut-brain signaling, metabolic hormones, food intake, and the emerging science of naturally regulating appetite, including how plant-derived compounds could complement nutrition, exercise, and other metabolic health strategies. This episode is essential listening for anyone interested in natural appetite suppression, hops extract, intermittent fasting, GLP-1, hunger hormones, weight loss, visceral fat, muscle preservation, metabolic health, gut-brain signaling, and science-backed strategies for controlling cravings and eating less. You'll Learn: How a patented compound extracted from hops activates bitter receptors in the gut to stimulate GLP-1, CCK, and PYY, the hormones involved in hunger and fullness Why clinical research found that hops extract reduced calorie intake by approximately 18%, and what that means for appetite control and overeating How a six-month clinical trial reported 5.5% body-weight loss, reduced visceral fat, and no detected average muscle loss Why hunger, cravings, and overeating involve complex hormonal signaling rather than simply a lack of willpower How natural appetite regulation may make intermittent fasting, extended fasting, and calorie restriction easier to maintain How hops-derived compounds differ from injectable
- 1 weeks ago43 min
The Easiest Treatment That Made Me 15 Years Younger : 1563
Explore House of Evolution: https://daveasprey.com/house-of-evolution/ Host Dave Asprey sits down with Dr. Tim Cook, a physician and longevity medicine expert who previously served as personal physician to two Governors General of Canada, to explore experimental gene therapy, biological age reversal, stem cell re-education, immune rejuvenation, muscle growth, and the emerging science of extending human lifespan. Recorded in the Amazon rainforest in Ecuador, the conversation explores three advanced longevity treatments Dave and Tim are working with through House of Evolution, their venture focused on expanding access to experimental therapies. They discuss how these technologies work, the early results they're observing, and why some treatments are currently available outside the United States. Dave reveals that after undergoing a two-day stem cell re-education treatment, blood testing approximately two months later indicated his immune system was 15.2 years younger. Tim explains how the procedure uses signaling molecules from umbilical cord blood stem cells to influence a patient's own immune cells before returning them to the body. They explore the potential implications for chronic inflammation, autoimmune conditions, and age-related immune dysfunction. The discussion turns to follistatin gene therapy, an experimental treatment designed to increase a protein involved in muscle growth and maintenance. Dave and Tim share preliminary results, including a reported average nine-year reduction in biological-age measurements, increased lean muscle mass, and reductions in body fat. They examine why preserving muscle and reducing visceral fat may be critical for longevity, particularly as anabolic resistance and sarcopenia become more common with age. They also explore klotho gene therapy, which targets a longevity-associated protein involved in kidney function, cognitive health, and aging. Tim describes early observations of substantially increased klotho levels following treatment, while Dave explains why this protein has become a major focus of his longevity research. The conversation also examines plasmid-based gene delivery, how it differs from directly editing human DNA, and the unanswered questions surrounding long-term safety and effectiveness. Dave and Tim challenge conventional thinking about healthspan, lifespan, and longevity escape velocity, discussing whether emerging treatments could eventually help people maintain youthful physical and cognitive function for decades longer. They examine how advanced biomarker testing and predictive models are being used to track biological aging and estimate changes in life expectancy. Finally, they look ahead to stem cell banking, genetic reprogramming, and regenerative medicine, including the possibility of rejuvenating a person's own cells and growing replacement tissues. They also address the high costs, limited availability, and regulatory challenges surrounding these technologies, emphasizing that many of the results discussed remain preliminary rather than clinically established evidence of age reversal. This episode is essential listening for anyone interested in biological age reversal, gene therapy, follistatin, klotho, stem cell re-education, immune rejuvenation, autoimmune disease, muscle growth, visceral fat, regenerative medicine, longevity escape velocity, and the future of anti-aging medicine. You'll Learn: How Dave's two-day stem cell re-education treatment was followed by a reported 15.2-year reduction in his measured immune age, and how the procedure works Why follistatin gene therapy is being investigated for muscle growth, sarcopenia, body composition, and biological aging How experimental plasmid-based gene therapies increase protein production without intentionally editing the human genome What early klotho gene therapy results suggest about protein levels, cognitive performance, kidney health, and longevity Why immune system aging, chronic inflammation, and visceral fat may contribute to age-related disease and physical decline How stem cell banking, cellular reprogramming, and regenerative medicine could shape the future of longevity treatments Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of bio
- 1 weeks ago24 min
How To Reverse Your Age For $5 Day (Budget Biohacking) : 1562
I have spent $2.5 million on this body, and Bryan Johnson spends about $5,400 a day on his. But does it need to be that expensive to biohack? So I gave myself a challenge: build a complete anti-aging protocol for $5/day, where every single thing on it has to be validated in humans, not mice. I could not spend the five dollars. In this video I'll show you the entire list and the two most powerful things I found… which cost nothing at all.You'll Learn:How to build a science-backed longevity routine for less than $5 a dayWhy omega-3s, GlyNAC, and magnesium may help slow aging and support cellular repairHow creatine, vitamin D, and L-theanine support brain health, muscle function, and focusWhy blackout curtains, red light, and blue-light-blocking glasses can improve sleep and circadian healthHow walking, morning sunlight, fiber, and quality sleep can improve longevity without expensive supplementsWhat Dave learned from spending $2.5 million on biohacking and why preventing damage is cheaper than repairing itTimestamps:00:00 — The $5/Day Challenge02:50 — Omega-3s: Aging Clock04:24 — GlyNAC: Master Antioxidant06:06 — Magnesium for Sleep07:50 — Creatine: Brain and Muscle09:39 — Vitamin D and Theanine12:09 — Light: Curtains and Bulbs15:52 — Free: Walking, Sun, Fiber19:00 — The Full Cost Summary20:09 — Why I Spent MillionsThank you to our sponsors!-Echo | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.-MyVitalC | Visit www.myvitalc.com/davesfav to unlock Dave’s discount-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.-iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestorelaser.com/DAVEConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Join my Substack: https://substack.daveasprey.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
- 1 weeks ago1h 15m
Avoid THESE "Healthy" Superfoods : 1561
We just had to bring this one back for you. Today, we’re digging once again into specifics about food that you haven’t heard on the show before. This one may very well influence you to rethink your “healthy” diet and change how you feel about food completely. To get there, I’m excited to welcome back Teri Cochrane, an integrative practitioner and pioneer in personalized healthcare. Teri is the founder of the Global Sustainable Health Institute® and developer of The Cochrane Method®, a future-facing algorithm for decoding the human body. Teri is also one of the world’s leading experts on dietary amyloids, which is a topic I love talking about.In today’s episode, we get into what amyloids are and how they turn on viruses, cause cancer, and shorten our lives. We also explore the dangers of oxalates and histamines, plus hacks to reduce and release them. Teri and I both have our own recipes for releasing oxalates that you can try at home (they’re surprisingly simple). We talk about how dirty poultry is killing us—and how superfoods like kale and almonds aren’t any better. We break down the benefits of regenerative farming, and share ways to make your dollar stretch if you can’t afford grass-fed meat. Plus, Teri tells us what she personally eats. Timestamps:00:00 — Intro02:01 — The Big 4 Metabolic Impairments08:21 — The Dangers of Oxalates12:02 — The Fifth Disruptor: Histamine16:22 — Becoming Your Own Body Interpreter28:41 — How Do We Get Off Oxalates?35:41 — Dave’s Recipe for Releasing Oxalates44:40 — Hacks for Histamines50:32 — Amyloid 101: What You Should Know56:56 — Should You Beware of B6?59:54 — What’s the Best Kind of Protein?Thank you to our sponsors!-Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.-BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.-Neuronic | Go to www.neuronic.online Code DAVE for $100 off-iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE irestorelaser.com/DAVEResourcesWebsite: tericochrane.comInstagram: @tericochranebeyondnutritionYouTube: @TeriCochraneThe Global Sustainable Health Institute: globalsustainablehealthinstitute.comRead: The Wildatarian Diet by Teri Cochrane What You Eat is Turning Your Genes On and Off – Teri Cochrane – #646Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprDanger Coffee: https://dangercoffee.com/discount/dave15?Dave's favorite supplements: https://www.shopsuppgradelabs
- 1 weeks ago56 min
How to Trigger Flow States From The 5 Brain Chemicals You Need : 1559
The Neuroscience of Flow, Peak Performance, Psychedelics, Trauma, Intuition & Consciousness with Steven KotlerHost Dave Asprey sits down with Steven Kotler, New York Times bestselling author and leading researcher in the neuroscience of flow, to explore how altered states of consciousness influence peak performance, mental health, creativity, intuition, and our perception of reality.Steven Kotler is a bestselling author of 17 books, including The Art of Impossible and We Are as Gods, and the founder of the Flow Research Collective. For decades, he has studied the neurobiology of peak performance, working with elite athletes, military personnel, and high-performing professionals to understand how people can reliably access flow states.Dave and Steven begin by exploring the neuroscience of flow and why it may be one of the most powerful altered states available without drugs. Steven explains how dopamine, norepinephrine, serotonin, anandamide, and endorphins contribute to the flow experience, why his research suggests caffeine can increase flow susceptibility, and how chasing the neurochemical high of peak performance can become dangerous.They discuss the darker side of flow training, including its potential risks for people prone to mania, the importance of recovery, and why attempting to remain in a flow state indefinitely can undermine performance. Steven shares how his training programs approach sleep, attention, and behavioral changes to help people access flow more consistently.The conversation then moves into psychedelics, ketamine-assisted therapy, and the neuroscience of trauma. Steven introduces emerging research suggesting that unresolved emotional patterns may involve the brain's predictive processing systems. Dave shares a personal experience involving Joe Rogan and how revisiting an early childhood memory changed his emotional response to public criticism.Dave and Steven also explore how the brain constructs reality, including the neuroscience of perception, sensory processing, and the flexible boundary between ourselves and our environment. They discuss how flow alters our sense of self, why the brain predicts what we experience before we consciously perceive it, and how these mechanisms may help explain certain spiritual and out-of-body experiences.Finally, Steven reveals new research investigating the neurological connections between flow, intuition, synchronicity, and purpose. He discusses emerging theories of consciousness, the role of information processing in subjective experience, and how artificial intelligence may change the future of human performance.You'll Learn:How flow states influence dopamine, norepinephrine, serotonin, anandamide, and endorphins, and why Steven's research suggests caffeine may help make the brain more susceptible to flow.Why chasing the neurochemical high of flow can become dangerous, how flow training may affect people prone to mania, and why sleep and recovery are essential for sustained peak performance.How ketamine-assisted therapy may help uncover forgotten emotional experiences and why Steven believes the brain's predictive processing systems play an important role in trauma.How the brain constructs our perception of reality, why sensory information reaches consciousness at different speeds, and what happens to our sense of self during altered states.Why flow may enhance intuition and how emerging neuroscience research is investigating connections between synchronicity, purpose, and the brain's information-processing systems.How Steven is using neuroscience, artificial intelligence, and years of flow training data to develop more accessible methods for improving focus, learning, and performance.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.Keywords: Steven Kotler, Dave Asprey, flow state, neuroscience of flow, peak performance, Flow Research Collective, dopamine, caffeine and flow, altered states, consciousness, psychede
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About The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.
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