How Estrogen Clearance Affects Breast Cancer & Menopause Risk with David & John | Mara Labs

Sarah introduces an Evolving Wellness episode on estrogen clearance, perimenopause/menopause, and why estrogen therapy isn’t one-size-fits-all, then interviews John and David from Mera Labs, whose work on sulforaphane began after both of their wives faced breast cancer. They explain how sulforaphane activates NRF2, supporting phase 2/3 detoxification, antioxidant responses, mitochondrial function, and mitophagy, and discuss circadian oscillations of NRF2. Sarah shares her experience of heavy bleeding, PMS, and low ferritin improving after several cycles on their product, with benefits also noted for her autistic teen. The guests differentiate stabilized sulforaphane from glucoraphanin products, describe synergy from added PEITC, discuss dosing timing, toxins/microplastics and endocrine disruptors, DIM questions, stress and vagal regulation, and note a rare microbiome-driven estrogen recycling condition linked to galactorrhea— Connect with John and Davidhttps://mara-labs.com/ https://www.instagram.com/themaralabs/ For the next week, Evolving Wellness loyal listeners can get an exclusive 25% off all Mara Labs products when you go to www.mara-labs.com/SARAHK and use code SARAHK at checkout. After one week, the code will return to the standard 15% off._________Timestamp:00:00 Microbiome Estrogen Recycling00:44 Why This Episode Matters03:14 Podcast Intro and Disclaimers04:27 Meet the Mera Labs Founders10:26 Sarah’s Estrogen Clearance Story14:57 Sulforaphane Science and Nrf231:30 DIM vs Sulforaphane Debate35:09 Minimize Menopause Formula37:54 Estrogen Therapy Prep41:58 Stress Epigenetics Reset44:38 Vagus Nerve Tools49:42 Sulforaphane Dosing Guide52:44 Toxins Microplastics Foods01:05:29 NRF2 Safety Wrap Up——— This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!________________________________________Get all my free guides and product recommendations to get started on your journey!https://www.sarahkleinerwellness.com/all-free-resourcesCheck out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) -  https://www.sarahkleinerwellness.com/coursesMy free product guide with all product recommendations and discount codes:https://www.canva.com/design/DAF7mlgZpJI/xVyE4tiQFEWJmh_Xwx8Kbw/view?utm_content=DAF7mlgZpJIFree Webinar on Light & Health (includes free light bulb guide) - https://www.sarahkleinerwellness.com/mycircadianapp-free-webinarGet Early Access to Podcast Episodes & my Seasonal Food Course + UVB+Red Light Therapy course for free -  https://open.substack.com/pub/sarahkleinerwellness/p/uvbred-light-protocol?r=5eztl9&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true