Do seizures drive the neuropathology of dementia? Insights from a post-mortem study

Welcome to the 31th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  This episode features a discussion with first author Dr Ifrah Zawar of the Brain article entitled: The association of seizure control with neuropathology in dementia We discuss an impressive post-mortem investigation of the link between seizures and the associated neuropathology of dementia. Higher tau and beta-amyloid burden is associated with Alzheimer's disease and also other forms of dementia. Listen as Dr Zawah discusses how seizures may drive neurodegeneration and that this, in turn, may lead to worse seizures and cognitive difficulties. This is an under-recognised and important problem in the clinical management of dementia. Check out the full article on the Brain website as part of the July 2025 issue: https://doi.org/10.1093/brain/awaf017 This episode was co-hosted, edited and produced by Xin You Tai and Roberto Bellanti, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.