Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity

Welcome to the 35th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  This episode features a discussion with first author Dr Laetitia Marcadet and senior author Chantelle F Sephton of the Brain article entitled: Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity. We discuss the interest concept of abnormal cellular energy metabolism in amyotrophic lateral sclerosis and, more broadly, across other neurodegenerative and neurological conditions. The authors outline their combined model of neuronal and, more uniquely, astrocytic compartments to identify response to lipid droplet targeting. Check out the full article on the Brain website as part of the Feb 2026 issue: https://doi.org/10.1093/brain/awaf404 This episode was co-hosted, edited and produced by Roberto Bellanti and Andreas Thermisticleous, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.