Surviving out of Spite

Parkinson's Disease & Gastroparesis: The Gut-Brain Connection Explained

August 12, 2026·43 min
Episode Description from the Publisher

Could Parkinson's disease begin in the gut? Emerging research suggests the connection between the gut and brain may be much stronger than we once believed.In this episode, Sam talks with Dr. Trisha Pasricha to explore the relationship between Parkinson's disease, gastroparesis, constipation, and other gastrointestinal disorders. Together, they discuss how digestive symptoms often appear years before neurological symptoms, why dopamine plays an important role in both the brain and the digestive tract, and what researchers are learning about the gut-brain axis.Dr. Pasricha explains why many people living with Parkinson's struggle with delayed gastric emptying, constipation, nausea, and other GI symptoms that can significantly impact quality of life. She also shares why treating digestive symptoms can be especially challenging, how specialists approach care, and what promising research may mean for future treatments.The conversation also dives into the importance of multidisciplinary care, the benefits of pelvic floor therapy, patient advocacy, and why understanding the whole body is essential when managing chronic illness.

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