Speaking of Women's Health

What is Progesterone Intolerance and Sensitivity?

May 13, 2026·33 min
Episode Description from the Publisher

Send us Fan Mail If your body seems to “flip a switch” after ovulation, you’re not imagining it and you’re not alone. Speaking of Women's Health Podcast host Dr. Holly Thacker talks through a lesser-known but very real problem: progesterone allergy and progesterone intolerance, often grouped under progestogen hypersensitivity. The most important clue is timing, with symptoms that reliably worsen in the luteal phase when progesterone rises and then ease when your period starts and hormones fal...

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