サイエントーク

281. 睡眠ってなんで必要?脳が無いクラゲだって眠る。

October 21, 2026·41 min
Episode Description from the Publisher

脳のないクラゲも、実は眠る! そもそも「寝ている」とはどういう状態?休むため・記憶の整理・脳のゴミ掃除では説明できない理由は?いま有力な「活性酸素とDNAの傷」説とは?など、人はなぜ眠るのかについて語ります。•─────• 💬 Pick UP 💬 •─────•コミュニティ「サイエントークラボ」書籍化プロジェクトやラボミーティングなど、科学×ポッドキャストを応援したい方へ!👇https://scien-talk.com/lab/•─────• 💬 Topics 💬 •─────•00:00 脳がないクラゲも眠る02:32 そもそも「寝る」とは?睡眠の3条件06:28 休むため説 眠っても省エネは1割弱09:04 記憶整理説 シナプスを細くする11:25 脳のゴミ掃除説 真逆の2つの結論16:18 クラゲを寝かせない実験 DNAに傷19:21 犯人は活性酸素 ミトコンドリアの暴走24:23 抗酸化物質でショートスリーパーになれる?29:04 生きた脳の活性酸素は測れるのか34:08 まとめ 僕らは細胞の塊38:56 お知らせ•─────• 💎 Reference 💎 •─────•Maquet P et al. Cerebral glucose utilization during sleep-wake cycle in man determined by PET (Brain Res 1990)https://doi.org/10.1016/0006-8993(90)91099-3Jung CM et al. Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans (J Physiol 2011)https://doi.org/10.1113/jphysiol.2010.197517Ultrastructural evidence for synaptic scaling across the wake/sleep cycle (Science 2017)https://doi.org/10.1126/science.aah5982Sleep drives metabolite clearance from the adult brain (Science 2013)https://doi.org/10.1126/science.1241224Brain clearance is reduced during sleep and anesthesia (Nat Neurosci 2024)https://doi.org/10.1038/s41593-024-01638-yResolving the mysteries of brain clearance and immune surveillance (Neuron 2025)https://doi.org/10.1016/j.neuron.2025.10.036The Jellyfish Cassiopea Exhibits a Sleep-like State (Curr Biol 2017)https://doi.org/10.1016/j.cub.2017.08.014DNA damage modulates sleep drive in basal cnidarians with divergent chronotypes (Nat Commun 2026)https://doi.org/10.1038/s41467-025-67400-5Mitochondrial origins of the pressure to sleep (Nature 2025)https://doi.org/10.1038/s41586-025-09261-ySleep Loss Can Cause Death through Accumulation of ROS in the Gut (Cell 2020)https://doi.org/10.1016/j.cell.2020.04.049Parp1 promotes sleep, which enhances DNA repair in neurons (Mol Cell 2021)https://doi.org/10.1016/j.molcel.2021.10.026•─────• 🧬 Infomation 🧬 •─────•🖥️ Official Website ⁠https://scien-talk.com/⬛ Xhttps://x.com/SciEn_TALK🟪 Instagramhttps://www.instagram.com/scien_talk/⁠⁠⁠🟥 YouTubehttps://www.youtube.com/@scientalk🔍 関連番組⁠⁠⁠⁠https://scien-talk.com/media/⁠⁠⁠🐈‍⬛ サイエンマニア | サイエンスっぽいマニアなハナシ💡 サイエンスポット | 10分で聴く最新科学ニュース🧠 脳パカラジオ🎙 ポッドキャスト研究室•─────• 🌏 Community 🌏•─────•🧪 LINE Open Chat「サイエンチャット」https://bit.ly/44cUYr5🥼 サイエントークラボhttps://scien-talk.com/lab/📋 ScienceBoard⁠⁠https://www.reddit.com/r/ScienceBoard/⁠📑 サイエンマガジンhttps://note.com/scientalk/m/mb7067d5dce94•─────• 📮 Contact 📮 •─────•おたよりやお問い合わせは下記へ🟩 LINE officialhttps://line.me/R/ti/p/@356egxqv🖋️ Google Formhttps://forms.gle/1NnybfxjZ6SHZEW6A📨 Mailscientalkclub@gmail.com

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