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- Today1 min
Season 2 Official Trailer: Lifespan with Dr. David Sinclair
What if aging is more reversible than we once thought? Season 2 of Lifespan with Dr. David Sinclair, A.O., Ph.D., explores the latest breakthroughs in longevity science - from epigenetic restoration to fasting, exercise, sleep, metabolism, and the emerging technologies that could help us live longer and healthier lives. Drawing on more than 30 years of research and conversations at the frontier of science and medicine, Dr. Sinclair breaks down complex discoveries into practical, evidence-based insights designed to help you understand how the body ages - and what may be possible to slow, optimize, or even reverse aspects of that process. This season features: • New episodes on fasting, exercise, metabolic health, and longevity science • The latest research on biological aging and cellular repair • Practical tools for healthier living backed by scientific evidence • New conversations around the future of medicine and human healthspan We're building the world's largest longevity community, focused on supporting medical research and living longer, together. Join us at https://lifespan.com Follow Lifespan: Instagram: https://instagram.com/lifespan X: https://x.com/JoinLifespan Follow Dr. David Sinclair: Instagram: https://instagram.com/davidsinclairphd Threads: https://threads.net/@davidsinclairphd X: https://x.com/davidasinclair Bluesky: https://bsky.app/profile/davidsinclairphd.bsky.social LinkedIn: https://linkedin.com/in/davidsinclairphd YouTube: https://www.youtube.com/@LifespanOfficial Watch or listen on YouTube, Spotify, and Apple Podcasts.
- 1 weeks ago59 min
What To Do For Longevity | Lifespan with Dr. David Sinclair Rewind
What are the most important things you can do today to live longer and stay healthier while doing it? In this first Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph.D., a Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, revisits the most impactful insights from his #1-ranked Season 1 series, combining updated commentary with key moments from across all eight episodes. The result is a focused, practical guide to the science of longevity – grounded in evidence and designed for real-world application. This episode covers: What to eat – and what to avoid – for long-term health How to think about exercise for longevity (not just performance) The role of cold and heat exposure Which supplements may support healthy aging Emerging medical interventions and what the science actually shows The tools and protocols Dr. Sinclair personally uses in his own routine Whether you're new to longevity science or looking to refine your approach, this episode brings together the most important principles in one place so you can better understand not just what to do, but why it matters. At Lifespan, our mission is to help you and your loved ones live longer, healthier lives while supporting medical research aimed at breakthroughs to extend all our lives. Join us at: https://lifespan.com. We’re building the world’s largest longevity community who will grow, learn, and live longer together. Subscribe here for new Lifespan show episodes every two weeks. __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in strong science – and products our team has personally used for many years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode – from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat content and muscle gains (Withings). If you’d like to learn more or try these tools: Ketone-IQ: Get 30% off your first monthly order at ketone.com/lifespan with code LIFESPAN WHOOP: Get a free WHOOP band plus one month free at join.whoop.com/LIFESPAN with code LIFESPAN Withings: Explore their smart health devices at withings.com/lifespan using code LIFESPAN __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research. The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
- Feb 23, 20221h 9m
Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8
In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook Matthew LaPlante's Social: Twitter To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Timestamps: Introducing Episode Eight: The Future of Anti-aging Medicine Thanking the Sponsors Modern Healthcare, Disease Detection, and Circulating DNA Wearable Monitors: A Dashboard for your Body Types of Health Sensors Big Data, Privacy, and Criminal Investigation Cutting-edge Testing and Biological Age Using Personalized Data to Inform your Diet Optimizing Exercise and Activity-mimetics Resetting the Aging Clock Repeatable Age Reversal and Safety Longer Life, Population Size, and Economics Skillbatical Putting in the Work for Longevity Thanking the Podcast Team and Wrapping Up Season One Options for Subscription and Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
- Feb 16, 20221h 1m
The Science of Keeping the Brain Healthy | Episode 7
In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook Matthew LaPlante's Social: Twitter To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Timestamps: Introducing Episode Seven: Aging of the Brain Thanking the Sponsors Ex-differentiation as a Driver of Aging The Brain Ages Slowly Cognitive Function and Plasticity Three Longevity Pathways: mTOR, AMPK, and Sirtuins Plant-based Diets and B-vitamins Homocysteine, Plaque, and Vasculature Fatty Acids Physical Activity Metformin NAD Boosters Increasing Blood Flor Sleep Overall Message: Keep your Brain Healthy Next Week’s Episode and the Future of Medicine Options for Subscription for Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
- Feb 9, 20221h 9m
The Science of Looking Younger, Longer | Episode 6
In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook Matthew LaPlante's Social: Twitter To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Timestamps: Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair Estrogen, Progesterone, and Menopause Thanking the Sponsors The Pinch Test, Epidermal Thinning, and Foot Ulcers Skin and Biological Aging Cellular Senescence, Ultraviolet Light, and Skin Aging Collagen, Keratin, and Skin Health A Quick Aside about Nails Autophagy and Retinoids Resveratrol, NAD Boosters, and Hyaluronic Acid Botox, Skin Peels, and Microneedling No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food Hair Loss and Hair Graying Topical Treatments, Pills, and Dihydrotestosterone Frickin Laser Beams: Low-level Laser Therapy Platelet-rich Plasma (PRP) Injections Hair Aging, Stress, and Gray Hair Reversal Targeting Aging Upstream Today’s Takeaways Subscription and Support Options For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
- Feb 2, 202258 min
Medical Interventions (TRT, HGH, Stem Cells, Peptides, etc.) For Longevity | Episode 5
In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Matthew LaPlante's Social: Twitter Timestamps: Kicking Off Episode Five: Interventions on the Cutting Edge Expressing Gratitude to the Sponsors Testosterone Replacement Therapy Human Growth Hormone Peptide Supplementation and Regenerative Signaling MOTS-c, Humanin, and Other Peptides Exosome Therapy A Primer on Stem Cells and Yamanaka Factors Stem Cell Aging and Cord Blood Banking The Therapeutic Potential of Stem Cells Cellular Reprogramming Resetting the Aging Clock The Future Looks Bright Next Week’s Episode: External Aging Subscription and Support Options For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
- Jan 26, 20221h 10m
NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4
In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted. Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Matthew LaPlante's Social: Twitter Timestamps: Kicking Off Episode Four: Longevity Molecules Thanks the Sponsors An An Additional Boost Beyond Adversity Mimetics Drugs vs. Supplements and Highlight Points Longevity Molecules Target the Survival Circuit NAD Boosters Nicotinamide Riboside Nicotinamide Mononucleotide NAD Intravenous Drips Bioavailability of NAD Boosters NAD and Cancer Resveratrol Red Wine and the French Paradox (0043:08) Fisetin and Quercetin Rapamycin and Rapalogs Spermidine Metformin Berberine Dr. Sinclair’s Protocol for Longevity Molecules Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge Options for Subscription and Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
- Jan 19, 20221h 11m
Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3
In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Timestamps: Introducing Episode 3: Exercise Hot Cold A Pernicisous Element Called Iron A Quick Primer on Free Radicals Review of Dietary Takeaways Sponsors (00:09:32 Biological Adversity & the Survival Circuit Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) & Communicators (e.g., Insulin) Get Off Your Butt Exercise Protects against Disease & Mortality Daily Step Count and Walking After Eating Exercise Activates AMPK and Creates More Mitochondria Vigorous Exercise, Hypoxia, the Electron Transport Chain Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation The Epigenome and Biological Age are Impacted by Exercise How to Measure your Biological Age Exercise Recommendations Wearables and Individualized Health Tracking The Importance of Weight Training Physical Activity & Senescent Cells Wrap-up & Takeaways Hyperbaric Oxygen Therapy Cold Therapy Applying Heat Adversity Mimetics Produce Endorphins A Basic Protocol for Mimicking Adversity Next Week: Molecules & Supplements Subscription & Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
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About Lifespan with Dr. David Sinclair
Join Dr. David Sinclair, Ph.D. in Lifespan, a popular health podcast that brings the cutting edge of aging and longevity science straight to you. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more.This podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.
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