JAMA Clinical Reviews

Medication Treatments for Alcohol Use Disorder

August 19, 2026·20 min
Episode Description from the Publisher

Naltrexone, acamprosate, disulfiram, and topiramate are effective but underused medications for treatment of alcohol use disorder. Author Stephen Holt, MD, MS, of Yale School of Medicine joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss first-line pharmacotherapy for alcohol use disorder and important safety, efficacy, and hospital initiation considerations. Related Content: Medications for Alcohol Use Disorder

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