Iron Culture presented by MASS

Ep 383 - Q&A: Imbalances, Fatigue, & REDs

July 22, 2026·1h 5m
Episode Description from the Publisher

In today's Q&A episode, the Erics work through a few listener questions. First they tackle upper/lower body imbalance — why lagging body parts usually call for improving training quality before adding volume, and why standout muscle groups can be maintained on surprisingly little work. Next is a long discussion on managing fatigue and exercise sequencing in high-frequency, non-traditional splits, including why the "48 hours between muscle groups" rule is more dogma than requirement and how to think about fatigue as continuous rather than categorical. The episode closes with a multifaceted question on REDs (relative energy deficiency in sport) — what it is, its warning signs, and the limits of what bloodwork can actually tell you.  Iron Culture is proudly presented by the MASS Research Review. Mostly because Helms and Trex are co-owners. massresearchreview.com If you're in the market for some new (ultra-high-quality) gym gear or apparel, be sure to use code "MRR10" for a 10% discount over at elitefts.com If you'd like to submit a question for a future episode, head over to: massresearchreview.com/ironculture Chapters 0:00 Intro 4:25 Fixing upper/lower body imbalance 6:39 Quality before quantity 9:03 Why standout muscles hold with less work 12:25 Fatigue & sequencing high-frequency training 17:58 How to actually sequence back-to-back days 23:56 Lifting "rules" set in concrete 26:09 Are lifters too worried about fatigue? 39:34 REDs (relative energy deficiency in sport) 40:51 Liver enzymes, creatinine & training stress 46:07 Cholesterol/LDL & other markers 1:00:21 Wrap-up

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