Hypertrophy Past and Present

058 Does mTOR determine your optimal training frequency?

June 29, 2026·1h 30m
Episode Description from the Publisher

In this episode of Hypertrophy Past & Present, Jake and Chris begin with a classic Clancy Ross full-body routine from the Silver Era, then move into a discussion about training frequency, mTOR, muscle protein synthesis, and whether training again before the previous hypertrophy stimulus has “finished” is actually a problem.Key topics include:• Clancy Ross’ 1940s full-body single set routine• Whether training a muscle every 48 hours can blunt hypertrophy• How repeated bout effect studies can be misapplied to training frequency• Why mTOR signalling is not the same thing as muscle growth• The role of oxidative stress and inflammation in post-workout recovery• How volume, frequency, stress, dieting, and athletic workloads affect recovery• Why the best training frequency is limited by recovery

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