
Most people think of hormones as reproductive. They are also metabolic, cardiovascular, skeletal, and neurologic — which is why hormone changes show up as fatigue, weight that won't move, broken sleep, brain fog, and lost strength long before anyone connects them.In this episode, Dr. Caitlin Prickett and host Jeffery Runyon take apart three hormones: estradiol, progesterone, and testosterone. They cover what the Women's Health Initiative actually found when researchers followed those women for eighteen years, why the type of progesterone a woman takes may matter more than whether she takes estrogen at all, and what the February 2026 FDA label changes mean for women who were taken off hormone therapy years ago and never restarted.The second half turns to men. Testosterone therapy has become an enormous business, much of it prescribed without a real workup. Dr. Prickett covers who genuinely has a testosterone deficiency, what the largest safety trial ever run actually found, what testosterone reliably delivers, and the risks worth naming out loud — including the one most often missed.Educational content, not medical advice for any individual.
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