From Models to Medicine

Episode 26: Bigger Models Won't Save Biomanufacturing

October 7, 2026·24 min
Episode Description from the Publisher

We sit down with Shawn Manchester, CEO of TripleBar, whose path from yeast DNA repair to metabolic engineering at MIT to biomanufacturing AI gave him a front-row seat to one of biotech's most underappreciated problems. Everyone funds discovery. Nobody funds manufacturing. And yet a molecule that can't be made reliably and cheaply at scale never reaches a patient. Shawn makes the case that biomanufacturing is where the real bottleneck lives, and why it's finally getting the AI attention it deserves. It's a refreshingly grounded conversation about what biological AI actually requires to work.

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