Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Ep. 584 "Slowing the Engine” – How GLP-1s Alter Your Gut Motility & Microbiome | Menopause, Perimenopause & Gut Health

April 23, 2026·21 min
Episode Description from the Publisher

Welcome to today’s Midlife Minute. In this episode, I answer listeners’ questions about GLP-1 medications and midlife weight changes. I explore how hormonal shifts, insulin sensitivity, muscle mass, and the gut microbiome influence the effectiveness of these drugs, and explain why they should be regarded as part of a broader metabolic and lifestyle framework. IN THIS EPISODE, YOU WILL LEARN: Why GLP-1 medications don’t necessarily fix the root cause of midlife weight gain  How declining estrogen can disrupt your appetite and satiety hormones The value of checking your fasting insulin to understand your insulin sensitivity level How inadequate protein can cause cravings for processed carbohydrates and fats Why preserving muscle mass is critical to prevent sarcopenic obesity   How GLP-1 medications affect digestion and gut motility The clinical factors that are considered when prescribing GLP-1 medications  Some simple daily habits to support your metabolic and microbiome health when using GLP-1 medications  Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

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