Protein Sparing Modified Fasting for Autophagy & Fat Loss with Vanessa Spina

In this episode, Dr. David Jockers sits down with Vanessa Spina, sports nutrition specialist, bestselling author of Keto Essentials, creator of the Tone ketone breath analyzer, and host of the Optimal Protein Podcast, for a deep dive on a groundbreaking new study out of the University of Nottingham, published in Clinical Nutrition in August 2025. You will learn why the old "you can only absorb 30 grams of protein per meal" rule doesn't hold up, what really happens to protein you eat beyond that amount, and why the popular anabolic-window advice to slam a shake right after your workout is largely a myth. Dr. Jockers and Vanessa then break down a randomized, controlled fasting-mimicking diet study that overturns the long-held belief that high protein blocks autophagy, and explain why a high-protein, calorie-restricted approach can outperform a low-protein one for visceral fat loss, ketone production, and metabolic health.  They close with a practical, hour-by-hour walkthrough of the protein-sparing modified fast (PSMF): what to eat, how much protein to target, how to structure refeed days, and how it compares to water fasting and Ozempic for appetite control.   In This Episode:  00:00 Protein Absorption Myth 00:14 Episode Intro and Study Teaser 05:29 Meet Vanessa and Study Setup 07:35 100g Protein Study Breakdown 12:17 Protein Timing and Real Life 17:48 Protein First for Satiety 23:55 Ketones and High Protein Keto 28:10 Stress Hormones and Growth Hormone 31:58 Autophagy Study Lead In 33:12 Why Human Trials Matter 34:52 Autophagy Headlines vs Reality 35:54 High Protein FMD Study Setup 39:01 Autophagy Still Upregulated 40:53 Visceral Fat and Metabolic Wins 44:12 PSMF One Day Weekly 44:58 Vanessa PSMF Results 47:22 Meals Macros and Refeeds 51:21 Ketones Hunger and Ozempic 55:27 Weekly Schedule and Whoosh 58:26 PSMF Meal Ideas and Tips 01:04:06 Water Fast vs PSMF 01:05:54 Wrap Up and Where to Find 01:06:56 Final Listener Outro   This podcast is sponsored by Paleo Valley's Turmeric Complex, a whole-food organic turmeric formula (not just isolated curcumin) blended with coconut oil and black pepper for absorption, plus ginger, rosemary, and cloves for extra anti-inflammatory and brain-support benefits. Go to paleovalley.com/jockers for 15% off your order.   A new season is the perfect time for fresh routines, and iRestore has led the way in red-light therapy for over two decades, trusted by more than 500,000 customers worldwide. The iRestore Elite laser hair growth system uses 300 lasers and 200 LEDs to help regrow thicker, healthier hair in as little as three months, and the Illumina face mask pairs triple-wavelength light therapy with a lightweight, cordless design to target fine lines, breakouts, and dullness in just 10 minutes a few times a week. Head to iRestore.com and use code DRJOCKERS for Labor Day savings on the Elite and Illumina bundle.   Tired of leaving a doctor's visit with more questions than answers? SuperPower Health runs one simple blood draw covering over 100 biomarkers — heart, liver, thyroid, hormones, metabolism, vitamins, minerals, and environmental toxins — and tracks your results over your lifetime with an on-demand clinician team to help you interpret them. Go to superpower.com and use code JOCKERS for $20 off your membership.   MasterClass keeps adding new classes, so there's never been a better time to get in. Right now, as a listener of this show, you get at least 15% off any annual membership at MASTERCLASS.com/DRJOCKERS. That's 15% off at MASTERCLASS.com/DRJOCKERS.  "Optimizing your protein acts just as well, if not better, than taking a semaglutide medication — without those side effects and a fraction of the cost."   Subscribe to the podcast on: Apple Podcast <p dir="ltr"