Pyroptosis: The Loud Cell Death Fueling Diabetic Foot Ulcers

Dr. G explains pyroptosis — an inflammatory form of programmed cell death driven by inflammasomes, caspase‑1, and gasdermin D — and how its pore‑forming, cytokine‑releasing shutdown can amplify inflammation. The episode explores how pyroptosis affects keratinocytes, fibroblasts, and macrophages in diabetic foot ulcers, potentially preventing healing by keeping danger signaling active, and why balancing this response matters for recovery.