Arjun Khemani Podcast

Aubrey de Grey: Longevity Escape Velocity, SENS & the End of Aging

October 1, 2026·32 min
Episode Description from the Publisher

My conversation with Aubrey de Grey, a biomedical gerontologist, founder of the LEV Foundation, and author of Ending Aging.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 - SENS vs. the Hallmarks of Aging2:47 - The Robust Mouse Rejuvenation experiment5:48 - Is SENS falsifiable?7:12 - CMLase and extracellular matrix damage10:28 - VEGF and extending lifespan in mice11:37 - Why longevity studies rarely get replicated13:05 - Michael Levin, bioelectricity & aging as information loss15:03 - Is partial reprogramming overhyped?17:32 - The most neglected areas of longevity research18:56 - Longevity escape velocity explained20:28 - Will people alive today live long enough?23:42 - How far are we from dramatically extending mouse lifespan?24:54 - What happens to society if we solve aging?27:20 - How longevity could reshape the global economy28:44 - Does mortality give life meaning?30:00 - Aubrey on the “pro-aging trance”31:34 - What Aubrey would do after solving aging This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com

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