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Arjun Khemani Podcast: Daily Summaries Delivered
by Arjun Khemani
A podcast about progress, philosophy, science, education, and the unconstrained human condition.
Latest Episodes
The most recent episodes — sign up to get AI-powered summaries of each one.
- Aug 8, 20261h 7m
Karl Pfleger: The Road to Solving Aging
Karl Pfleger is the founder of agingbiotech.info and an investor in several rejuvenation startups.Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 - Why lifespan is the wrong metric for aging progress7:28 - Is the hallmarks of aging expanding a problem?11:36 - Structures vs. processes: the key distinction in aging targets16:14 - Why Karl favors divide-and-conquer rejuvenation over slowing aging22:07 - Whole-body replacement and organ/cell-level rejuvenation26:56 - Is partial epigenetic reprogramming the kill-shot for aging? 35:24 - CMLase and reversing crosslink damage40:57 - Can AI just solve aging automatically?46:57 - Funding misallocation and the case for more aging biotech companies/VC57:28 - Objections to eliminating aging — and why none hold up1:01:27 - Karl critiques Bryan Johnson’s “Don’t Die” This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com
- Jul 1, 20261h 9m
David D. Friedman: Death, Taxes, and Other Solvable Problems
David D. Friedman is an anarcho-capitalist economist. He is the author of The Machinery of Freedom, Future Imperfect, and several other books. Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 – The economics of longevity8:05 – Epigenetic reprogramming12:37 – Overpopulation and the “ultimate resource”16:33 – Fluid vs. crystallized intelligence, aging and political power20:46 – Cryonics24:35 – AI, open source, and the surveillance state28:29 – Zcash, privacy, and cryptocurrency41:12 – Taxes, government, and money supply50:27 – A poem about tyranny and benevolence56:42 – Education and its resistance to change1:05:42 – Argentina, Milei, and planning for an uncertain future This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com
- Apr 4, 20261h 22m
Sean Bowe and Dev Ojha: Architecture of Freedom
Sean Bowe is a core cryptographer and engineer who played a major role in building Zcash’s technology.Dev Ojha, also a cryptographer, is the founder of Osmosis. He is now working on helping Zcash scale and go post quantum.Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 - Why Dev’s working on Zcash12:24 - AI is surveillance’s ultimate weapon13:33 - Encrypted money must scale15:49 - Compliant “privacy” is an oxymoron19:25 - PIR for scaling Zcash36:35 - How Tachyon and PIR work hand in hand43:47 - Quantum recoverability47:18 - Is quantum the last cryptography problem?51:41 - Easier coinholder voting process1:03:15 - Zcash roadmap1:17:34 - What Zcash looks like at scale This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com
- Oct 11, 20251h 41m
Sean Bowe and Jack Grigg: Encrypted Money at Planetary Scale
Sean Bowe and Jack Grigg aka str4d are both cryptographic engineers working on the Zcash protocol. Sean’s latest project is Tachyon, intended to bring encrypted money into the hands of 8 billion people. Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 - Project Tachyon10:20 - Privacy can’t be an afterthought for a protocol15:24 - Encrypted Bitcoin22:11 - Soundness bug in original sprout pool30:15 - Sapling33:00 - A decade of progress39:04 - Zcash’s anonymity set51:29 - Using private money as a passthrough doesn’t work56:04 - The importance of ledger indistinguishability58:30 - The ultimate privacy stack1:05:58 - Tachyon removes all cryptographic bottlenecks of encrypted money1:08:16 - What’s next after Tachyon?1:15:25 - Weightless blockchains?1:18:24 - Ragu1:19:44 - What the next 12 months look like for Jack and Sean1:31:22 - “Everything worth doing is worth doing on ambitious timelines.” — Sean1:32:16 - Sean’s advice for young engineers1:34:18 - What got Sean and Jack into Zcash? This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com
- Jul 11, 202558 min
Samo Burja: Building an Immortal Society
My conversation with Samo Burja, founder of Bismarck Analysis. He chairs the editorial board of Palladium Magazine.Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Click here to support my work.Timestamps0:00 - Intro1:18 - Live players5:41 - Great Founder Theory11:20 - Our material technology rests on our social interactions14:23 - Optimism, pessimism, and human agency23:21 - Operationalized knowledge25:22 - Lost and dead traditions of knowledge27:34 - Tradition of criticism29:36 - The most important piece of knowledge to preserve32:27 - Common features of declining societies39:18 - Are the Spartan warriors overrated and just had very good PR?42:07 - DOGE and bureaucracy in America45:28 - The machinery of freedom47:43 - Tech Samo is most excited about over the next 5 years50:10 - Curtis Yarvin and the orbital authority55:01 - Samo’s advice for young peopleFollow me on X.Follow Samo on X. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com
- Jun 3, 20251h 34m
Zooko Wilcox and Josh Swihart: Unstoppable Private Money
My conversation with Zooko Wilcox and Josh Swihart on unstoppable private money.Zooko Wilcox is a legendary cypherpunk and one of the founders of Zcash—private, digital money.Josh Swihart is the CEO of Electric Coin Company, the team behind the Zcash protocol and the Zashi wallet app.Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 - Maya Protocol integrates with Zcash3:52 - Coinbase social engineering attack7:43 - Private money negates capital controls14:13 - Privacy comes from money at rest18:24 - The Zashi effect and future roadmap25:11 - Project Tachyon39:10 - Zcash’s anonymity set doesn’t depend on the number of its users45:37 - Turnstiles in Zcash and the 2018 inflation bug57:28 - “ZK” has become a marketing stunt among crypto projects59:48 - On Binance delisting ZEC1:01:35 - A transition toward using crypto as it was originally intended1:04:52 - Should exchanges use transparent addresses?1:17:38 - Coin holder voting in Zcash1:23:38 - Sci-fi influence1:28:37 - Gary Gensler1:29:40 - Why I like ZcashFollow Zooko on X.Follow Josh on X. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com
- Mar 15, 202552 min
Ethan Thornton: The Future of Warfare
My conversation with Ethan Thornton, founder of Mach Industries.Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Click here to support my work.Timestamps0:00 - Intro1:07 - Why Mach needs to exist3:16 - Early experiments5:07 - Dropping out of MIT8:36 - Raising $85 million at 19 years old11:20 - Decentralized vertical supply chains13:54 - The most important domain of the next century15:55 - Betting on hydrogen18:11 - Overview of Viper and Glide21:06 - Building feedback loops across teams25:29 - Facing regulatory hurdles28:19 - Knowing when to be risk tolerant29:54 - Time until China invades Taiwan31:45 - The future of warfare42:29 - Takeaways from the (unmanned) war in Ukraine48:23 - Biggest influences on Ethan’s life49:37 - Mach’s long-term planFollow me on X.Follow Ethan on X. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com
- Feb 26, 20251h 15m
Peter Boghossian: Moral Relativism and The Future of The West
My conversation with philosopher and author Peter Boghossian.Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Click here to support my work.Timestamps0:00 - The enlightenment5:51 - The dangers of moral relativism21:28 - Modern education is failing us31:14 - What’s worth preserving in the West37:00 - Is wokeism filling the void left by atheism?38:04 - The spread of Islamism45:49 - Speech is not violence49:11 - Derangements of science52:48 - The myth of the framework56:34 - Why you should learn epistemology58:05 - The instinct to belong trumps what’s true1:02:44 - Chasing likes versus pursuing truth1:05:08 - What is Peter most optimistic and most pessimistic aboutFollow me on X.Follow Peter on X. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com
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About Arjun Khemani Podcast
A podcast about progress, philosophy, science, education, and the unconstrained human condition.
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