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21 in 21: Daily Summaries Delivered
by Hosted by Haley Berkoe
Haley Berkoe asks some of the biggest names in bitcoin and Silicon Valley 21 questions in 21 minutes, from the personalities you know and love to tech’s unsung heroes. A new episode drops when someone stops by Presidio Bitcoin.
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- 4 days ago20 min
21 in 21: 0xSero on Local AI, Open Models, and Benchmarking
0xSero joins Haley Berkoe on 21 in 21 to discuss local AI, open models, and his soon-to-be-released platform for benchmarking open models and hardware (local.ai). He explains how his team benchmarks models and hardware, why local AI is becoming more capable and affordable, and why ownership and control matter as more people build their work around AI. They also discuss open-source AI culture, agentic payments, and what people can do to start experimenting with local models. FOLLOW: https://x.com/0xsero https://x.com/HBerkoe LINKS https://local.ai
- 1 weeks ago25 min
21 in 21: Bradley Axen on Buzz, goose, and AI at Block
Haley Berkoe sits down with Bradley Axen, who is leading many of Block's AI initiatives, including Buzz, a new open-source collaboration platform designed for humans and AI agents to work together. He also helped create goose, the open-source AI agent that was later donated to the Agentic AI Foundation under the Linux Foundation. They discuss how Block is using AI internally with tools like Builder Bot to help engineers navigate massive codebases, automate incident response, and collaborate more effectively. Brad also shares his thoughts on where open-source AI is headed, why model flexibility matters, and how new open source AI contributors can get involved. FOLLOW: https://x.com/bradleyaxen https://github.com/baxen https://x.com/HBerkoe LINKS: https://buzz.xyz https://goose-docs.ai TIMESTAMPS: 0:00 Introduction & Brad's journey into AI at Block 2:17 What goose is and why developers should care 3:15 Open models, local inference, and switching between providers 5:00 Do AI models perform better with their own coding harness? 6:40 Why enterprises benefit from model flexibility 8:25 Why AI inference is becoming critical infrastructure 9:16 How Block is approaching AI and open-source collaboration 10:25 Builder Bot: Block's internal AI assistant 13:50 Buzz: the future of collaborative AI workflows 15:47 Will Buzz replace Slack? 20:00 How AI is changing the role of engineers 21:45 Advice for getting started in open-source AI 24:22 Where to follow Brad's work
- 1 weeks ago23 min
21 in 21: Mic Neale on goose, Mesh LLM, and Open Source AI
Mic Neale, a member of the Spiral team at Block and a core developer of goose, an open source AI agent, joins Haley Berkoe on 21 in 21 to discuss goose, Mesh LLM, and open source AI. Mic shares how goose has evolved from a desktop app and CLI into the goose Development Kit (GDK), making it easier for developers to build AI applications. He also explains how Mesh LLM pools idle compute across devices, why local models and peer-to-peer infrastructure matter, and where he sees the overlap between bitcoin and open source AI. As a longtime open source contributor, Mic closes with advice for anyone looking to get involved in open source projects. FOLLOW: x.com/michaelneale x.com/HBerkoe LINKS goose-docs.ai meshllm.cloud spiral.xyz TIMESTAMPS 0:00 Intro & welcome 1:00 Mic's background 3:35 What makes the open-source AI community different? 5:02 What is goose? 6:55 Running AI models locally with goose 8:02 Why goose was designed differently from other AI agents 10:15 Mesh LLM and sharing unused compute across devices 13:20 Could you earn money by contributing inference? 17:05 Joining Spiral and the connection to bitcoin 19:11 The overlap between open-source AI and bitcoin 20:00 Career advice for aspiring open-source developers 22:00 Why open source still matters in the AI era 23:22 Where to find Mic online
- 4 weeks ago22 min
21 in 21: Patrick Ball on Using Bitcoin and AI to Defend Human Rights
Patrick Ball, Director of Research at the Human Rights Data Analysis Group, joins Haley Berkoe on 21 in 21 to discuss how data, bitcoin, and AI can help defend human rights. Patrick explains how his team uses statistics to document mass violence, how bitcoin can help protect the integrity of human rights evidence, and why nonprofits need decentralized tools and local AI to stay resilient. hrdag.org
- May 21, 202622 min
21 in 21: Calle on Cashu, Clawi, and AI Agents
On this episode of 21 in 21, Calle discusses his work on Cashu, Bitchat, and Clawi. He explores how AI agents could use bitcoin-native payments and why privacy-preserving infrastructure matters in an increasingly agentic internet. Calle also reflects on his journey down the bitcoin rabbit hole, from early work on Lightning infrastructure to building eCash systems, and shares his perspective on the evolution of AI agents. https://x.com/callebtc https://clawi.ai/ https://bitchat.free/ https://cashu.space/
- Apr 16, 202626 min
21 in 21: Linn Bieske on Hack-Nation and Building Global AI Communities
Linn Bieske, Co-Lead of the AI & Technology Track at the MIT Club of Northern California (CNC), AI Product Manager, and Co-Founder of Hack-Nation, joins Haley Berkoe on 21 in 21. They discuss the upcoming Hack-Nation event on April 25 and Spiral’s sponsored challenge exploring what becomes possible when AI agents can earn using the Lightning Network. Linn also shares her perspective on what motivates today’s AI builders, how to design experiences that lead to something more lasting than a 24-hour sprint, and why community and collaboration matter so much. Apply by April 19 to join the upcoming hackathon, or follow along for the next one. https://hack-nation.ai/ https://www.linkedin.com/in/linn-bieske-189b9b138/ https://www.linkedin.com/company/hack-nation/ https://www.linkedin.com/in/haleyberkoe/ https://spiral.xyz/
- Apr 7, 202625 min
21 in 21: Rainey Reitman on Transaction Denied and Financial Censorship
Rainey Reitman joins 21 in 21 for a conversation on financial censorship, free speech, and her new book, Transaction Denied: Big Finance’s Power to Punish Speech. Rainey co-founded Freedom of the Press Foundation and serves on the board as president. She also spent 11 years at the Electronic Frontier Foundation, first as Activism Director and later as Chief Program Officer. Drawing on years of work in civil liberties advocacy, Rainey explains how lawful speech can still lead to frozen accounts, denied payments, and exclusion from the financial system. She also shares how these issues connect to journalism, whistleblowers, privacy, and Bitcoin’s promise, and limits, as a censorship-resistant tool. Links to Book: Amazon: https://a.co/d/04WK0Qek Bookshop: https://bookshop.org/lists/transaction-denied-big-finance-s-power-to-punish-speech Audio: https://www.audible.com/pd/Transaction-Denied-Audiobook/B0FJZRQXXR?source_code=AUDORWS0718179KY7 A portion of every book sale goes to support Freedom of the Press Foundation. “In her timely and necessary book, Reitman illuminates the shocking and widespread censorship exerted by the American banking system, details how Orwellian financial surveillance and control has become the norm, and makes a powerful case for why we must push for change if we want to preserve freedom and privacy in the 21st century.” — Alex Gladstein, Chief Strategy Officer, Human Rights Foundation Follow: https://x.com/RaineyReitman https://x.com/FreedomofPress
- Mar 19, 202622 min
21 in 21: Michael Saylor on Bitcoin, AI, and Advice for Builders
Michael Saylor joined Haley Berkoe on 21 in 21 for a rapid-fire conversation on bitcoin, AI, and what’s coming next. He shares what’s top of mind for 2026, why he sees this year as a major turning point, and how he thinks bitcoin could evolve as digital capital beneath new layers of credit and currency. Then, Saylor gets into how AI will radically transform civilization, and how that shift could make bitcoin even more important in a world where autonomous agents need to transact constantly with digital capital. He points to Strategy’s use of AI in creating digital credit products like Stretch (STRC), and shares the kinds of bitcoin products he hopes to see, from deeper integration into everyday technology to applications powered by bitcoin. Saylor emphasizes that we’re entering one of the most fertile periods ever for building, and encourages builders and young people to spend a lot of time learning AI tools and continually pushing themselves to create something new and useful. There are also a few fun detours into MIT prank stories and the AI-generated X profile images he’s become known for. Follow: https://x.com/saylor https://x.com/HBerkoe https://www.youtube.com/@PresidioBitcoin Links: https://www.michael.com https://www.hope.com https://www.uncute.com/products/here-comes-bitcoin
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About 21 in 21
Haley Berkoe asks some of the biggest names in bitcoin and Silicon Valley 21 questions in 21 minutes, from the personalities you know and love to tech’s unsung heroes. A new episode drops when someone stops by Presidio Bitcoin.
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