Xtalks Life Science Podcast

Tackling Fluid Overload: Nuwellis CEO Mike McCormick on What to Do When Diuretics Don’t Work

September 16, 2026·12 min
Episode Description from the Publisher

In this week’s episode of the Xtalks Life Science Podcast, host Dr. Mohammad Ali speaks with Mike McCormick, President and CEO of Nuwellis, about fluid overload, the heart-kidney connection and what happens when diuretics stop working as expected. Mike explains that fluid overload is “not simply a cosmetic swelling.” Persistent congestion can make breathing difficult, reduce appetite and even make it hard for patients to lie flat. He also describes the cardiorenal balancing act, where worsening heart function can prompt the kidneys to retain more water and sodium, adding further strain on the heart. He discusses how clinicians recognize diuretic resistance and where ultrafiltration may fit as another “tool in the toolbox” for removing excess fluid when medications are no longer enough. Tune in to hear why Mike looks beyond the numbers to patient outcomes, why “How did the patient do?” remains a critical question and why pediatric patients are “not just small adults.” For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/   For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/ Follow Us on Social Media Twitter: https://twitter.com/Xtalks Instagram: https://www.instagram.com/xtalks/ Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured

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