What I'd Tell My Family with Dr. Todd Levine

APOE4 and Alzheimer’s: How Genetics Inform Prevention, Testing, and Family Decisions

June 29, 2026·27 min
Episode Description from the Publisher

Welcome back to "What I'd Tell My Family." In today’s episode, we take a deep dive into one of the least discussed, yet most powerful predictors in neurology: the APOE4 gene and its connection to Alzheimer’s disease. Joined by Dr. Todd Levine, we unravel what it means to carry APOE4, the difference between having one or two copies, and how genetic information can shape the way we approach risk, prevention, and family conversations about memory loss. We address the big questions: Who should ge...

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