Jul 31 2026 This Week in Cardiology

Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588 II Another Failure of Posterior Wall Isolation CORNERSTONE-AF Trial https://doi.org/10.1093/eurheartj/ehag486 CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186 PVIOTAL IDE Trial 10.1016/j.hrthm.2025.08.018 External Link III First Line AF ablation – One new study and a discovery about a second one Catheter Ablation vs AAD for First-line Treatment of AF 10.1016/j.hrthm.2025.07.061 External Link EAST-AFNET 4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2019422 Cardiology Trials Substack https://cardiologytrials.substack.com/p/summary-and-discussion-of-east-afnet IV Left Atrial Appendage Closure Meta-analysis Long-Term Efficacy and Safety of LAAC vs OAC -- Meta-analysis https://academic.oup.com/europace/article/28/7/euag159/8739567 V Prevention of AKI after Cardiac Surgery: MERCURI-2 MERCURI-2 Study https://jamanetwork.com/journals/jama/fullarticle/2852324 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net