OpenAI's chief scientist wants to slow down | E30

This Week In Startups is made possible by:PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at paypal.launch.coToday’s show:OpenAI&#39;s chief scientist wrote a lengthy manifesto arguing that no lab has solved alignment, mere days after GPT-6 Astra shipped. Jason and Lon are joined by Tudor Achim of Harmonic, Alex Elias of Qloo, and Ahmed Ahres of Reactor to figure out if that&#39;s genuine alarm being expressed or just another pre-IPO sales pitch and play for regulatory capture.Plus news broke while we were recording! OpenAI is claiming to have solved a second Millennium Prize problem, after a 25-year-plus weight. AND, who is paying influencers to tell you AI is wonderful/harmful? And why?Guests:Tudor Achim on X: https://x.com/tachimHarmonic: https://harmonic.fun/Alex Elias on X: https://x.com/apeQloo: https://www.qloo.com/Ahmed Ahres on X: https://x.com/BoudatwReactor: https://reactor.inc/Relevant Links:Jakub Pachocki, &quot;An Alien Mind&quot; — https://openai.com/index/an-alien-mind/GPT-6 Astra — https://fortune.com/2026/09/03/openai-debuts-gpt-6-astra-computer-use-greg-brockman-says-start-of-agi/OpenAI: &quot;On the Navier–Stokes Millennium Prize Problem&quot; — https://openai.com/index/navier-stokes-solution/ControlAI — the nonprofit that sponsored the SciShow episode — https://controlai.org/New York Times (Eli Tan), &quot;Corporate America Is Getting Hooked on Open-Source A.I.&quot; — https://www.nytimes.com/2026/09/04/technology/open-source-ai-companies.htmlArtificial trailer and the cast → https://variety.com/2026/film/news/artificial-trailer-andrew-garfield-openai-biopic-1236802616/Timestamps:0:00 &quot;An Alien Mind&quot;3:08 AI psychosis, marketing, or half a mile ahead on the racetrack?12:52 The Manhattan Project analogy15:20 Tudor: if it&#39;s really that dangerous, the answer is nationalization17:02 Regulatory capture: Bill Gurley at All-In, Sacks, and who can afford to be regulated20:37 The influencer propaganda tape23:22 BREAKING: OpenAI solves the Navier-Stokes Millennium Prize problem28:53 The Hank Green / SciShow video sponsored by ControlAI32:11 Fogging and flooding46:47 UBS will require AI skills from its 2027 graduate56:41 How LAUNCH hired its associates-in-training57:18 NYT: Corporate America is getting hooked on open-source AI1:04:16 Alex on Qloo&#39;s shift from NYT film critics on payroll to small specialized models1:09:35 First look: the &quot;Artificial&quot; teaser trailer1:14:34 Sam Altman&#39;s bunker, Peter Thiel, and casting rundownSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta,<