The Tox Lab

Episode 81: Alexander Shulgin – The Man Who Shaped Modern Psychedelics

June 15, 2026·26 min
Episode Description from the Publisher

This week on The Tox Lab, we’re discussing the life and work of one of the most influential figures in psychedelic chemistry, Alexander “Sasha” Shulgin.From his early career at Dow Chemical to his pioneering work with psychoactive compounds, Shulgin’s career helped shape the modern landscape of psychedelic research.We discuss his fascination with psychedelics, his meticulous approach to self-experimentation, and his synthesis and investigation of hundreds of compounds, including his role in the rediscovery of MDMA and the publication of PIHKAL and TIHKAL.Join us as we examine the science, stories, and controversies surrounding Alexander Shulgin, and consider how one chemist helped shape our modern understanding of psychedelic drugs.Link to Shulgin's laboratory notebooks: https://www.erowid.org/library/books_online/shulgin_labbooks/ Disclaimer: All opinions are our own.Find us on instagram: @the_tox_labEmail us here: thetoxlab@gmail.comCheck out our new website: https://thetoxlab.co.uk/ Support us here: https://buymeacoffee.com/thetoxlab

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