The Occupational Safety Leadership Podcast

Measuring Worker Fatigue with James Walsh of Hyperion Biotechnology - part 2

June 27, 2026·23 min
Episode Description from the Publisher

Fatigue contributes to accidents, now there's an accurate test.  This is part 2 of fatigue testing using non-invasive saliva chews with James Walsh. Hyperion Biotechnology developed a non‑invasive saliva‑based test that measures biological markers linked to fatigue, stress, and readiness for duty. The goal is to give employers an objective way to identify when workers may be too fatigued to perform safely — especially in high‑risk environments. Guest information - James Walsh https://www.linkedin.com/in/james-walsh-675193129/  Hyperion Biotechnology - https://hyperionbiotechnology.com/    🔬 1. What the Test Measures What is measured is a proprietary, patented biomarker for fatigue. It’s not cortisol. The peptide ratio I describe is the Fatigue Biomarker Index is a biomarker assay that is exclusive to Hyperion (that we developed with the Army and Air Force).   🧪 2. How the Test Works Employees provide a simple saliva sample (no needles, no medical staff required). The sample is analyzed using Hyperion’s proprietary assay. Results indicate whether the worker is: Borderline fatigued Significantly fatigued This creates an objective fatigue score, rather than relying solely on self‑reporting or supervisor observation.   🛡️ 3. Why It Matters for Occupational Safety Fatigue is a major contributor to: Reduced reaction time Poor decision‑making Increased error rates Higher injury risk Hyperion’s test gives safety leaders a data‑driven tool to identify fatigue before it leads to incidents — especially in: Transportation Manufacturing Military operations Shift work High‑hazard environments Employees receive a personalized report with strategies to help reduce their fatigue.   📌 Key Takeaways for Safety Leaders Saliva testing provides objective fatigue data. Non‑invasive collection makes it practical for daily or periodic use. Results help guide fit‑for‑duty decisions. Supports a proactive approach to fatigue risk management.

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