How does touch lead to pain or pleasure?

Pain and pleasure seem like simple facts of life, but they are far from it. Neuroscientists still cannot say why physical pain differs from psychological pain, for instance, nor why a loved one’s touch soothes while a stranger’s touch repels. To explore the science behind these sensations, Janna Levin talked to Ishmail Abdus-Saboor, a neuroscientist at Columbia University’s Zuckerman Institute. Their conversation covers how pain serves an evolutionary purpose, how researchers measure pain and pleasure in the lab despite the absence of any objective biomarker, and how touch functions as a social and emotional signal, not just a sensory one. Abdus-Saboor also describes his work with naked mole rats — a species that barely feels pain, shows no signs of aging, and lives in colonies built almost entirely on touch — and the ethical trade-offs when studying sensations in animals that cannot describe what they feel.