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The Holistic GLP-1 Podcast with Elizabeth McGann

How to Stop GLP-1's Without Gaining the Weight Back (with Dr. Holly Wyatt)

February 24, 2026·52 min
Episode Description from the Publisher

One of the biggest fears women have when starting GLP-1 medications isn't losing the weight —it's what happens after. Do I have to stay on this forever? Will I regain the weight if I stop? Is there a right way to transition into maintenance? In this powerful, science-grounded episode, Elizabeth sits down with Dr. Holly Wyatt—endocrinologist, obesity medicine physician, and author of Losing the Weight Loss Meds—to explore what actually helps people keep weight off long-term, with or without medication. This conversation bridges medical science with real-world behavior change, mindset, identity, and lifestyle—and fits seamlessly into the Holistic GLP-1 Method. If you're thinking about maintenance, transition, or long-term freedom from food struggle, this episode is essential listening. *** SHOW NOTES [ 00:00 ] Introduction [ 02:30 ] Why Dr. Wyatt wrote a book about getting OFF GLP-1s [ 03:55 ] Do you really have to stay on GLP-1s for life? [ 04:25 ] Why weight regain happens [ 05:20 ] What the data tells us (and what we're still learning) [ 07:45 ] GLP-1s as "training wheels" [ 08:30 ] Begin with the end in mind [ 09:05 ] The three pillars of successful maintenance [ 10:00 ] Why environment can make or break maintenance [ 11:20 ] Blood sugar, appetite & GLP-1 physiology (made simple) [ 13:25 ] Can lifestyle replace medication effects? [ 14:40 ] Quality vs. quantity of weight loss [ 15:20 ] The Appetite Reset Meal [ 17:40 ] Why breakfast matters more than you think [ 19:30 ] No dogma: one size never fits all [ 20:05 ] The Satiety Snack strategy [ 22:30 ] Physical activity is for maintenance, not weight loss [ 23:05 ] Metabolic flexibility explained [ 24:30 ] Why some people's weight never changes [ 26:10 ] The Supper Club strategy [ 27:55 ] The #1 mistake when stopping GLP-1s [ 29:40 ] Weight loss vs. weight maintenance are different phases [ 31:00 ] The 10-week transition plan overview [ 32:30 ] Microdosing: what we know and don't know yet [ 35:10 ] Side effects: what's normal and when to get help [ 37:35 ] Freedom as the real goal [ 42:15 ] Why weight loss alone doesn't create happiness [ 45:25 ] Food, addiction & filling life with more than food [ 46:15 ] Mind state vs. mindset [ 47:05 ] Identity shifts and long-term success [ 48:40 ] Menopause, midlife & possibility [ 52:00 ] Trusting your body without medication [ 54:00 ] Where to find Dr. Holly Wyatt [ 55:00 ] Final reflections *** 🔗 Mentioned in This Episode: Learn how to activate GLP-1 naturally and silence cravings! CLICK HERE TO GET ⇒ Free Masterclass: Freedom From Food Noise: https://go.elizabethmcgann.com/start *** Get Connected with Elizabeth McGann: Coaching Website: http://www.ElizabethMcGann.com Instagram: http://www.instagram.com/elizabethmcgann Facebook: https://www.facebook.com/ElizabethMcGannWellness LinkedIn: https://www.linkedin.com/in/elizabethmcgann X/Twitter: https://twitter.com/ElizabethMcGann *** Learn more about Dr. Holly Wyatt Instagram: https://www.instagram.com/drhollywyatt/?hl=en Website and Book: https://www.weightwisdom.com/

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