The Future of Medicine

Samuel Klein on GLP-1 Revolution, Metabolism, and the Future of Obesity Medicine

May 24, 2026·27 min
Episode Description from the Publisher

Dr. Samuel Klein, Division Chief and William H. Danforth Professor of Medicine and Nutritional Science at Washington University Medicine, joins The Future of Medicine for a conversation about obesity, metabolism, insulin resistance, and the revolution sparked by GLP-1 medications like Ozempic. In this episode, Dr. Klein explains why obesity is far more biologically complex than many people realize — and why some individuals with obesity remain metabolically healthy while others develop diabe...

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