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The Evidence Based Rheumatology Podcast: Daily Summaries Delivered
by Michael Putman
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- 2 weeks ago11 min
E135: IL17 and a GLP1?
Really interesting study this week comparing the IL17 inhibitor ixekizumab WITH the GLP1 inhibitor tirzepatide to ixekizumab alone. Raises some interesting questions about what worked here and whether or not it matters how it worked. Paper: https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70134 Newsletter: http://autoimmunedevreport.com/
- Apr 17, 202614 min
E134: Brepocitinib in Dermatomyositis (VALOR)
Great trial this week looking at brepocitinib in dermatomyositis. Looks like a winner, expect it will be approved. Where it fits in our approach to IIM is an open question, but nice to have another option. Study: https://www.nejm.org/doi/10.1056/NEJMoa2503531 JC Companion: https://autoimmunedevreport.substack.com/
- Mar 19, 202615 min
E133: Obinutuzumab for SLE (ALLEGORY)
Good RCT this week, investigating the CD20 B cell inhibitor obinutuzumab for SLE. Sign up for my newsletter if you would like to have a read-along companion piece! Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2516150 Landing Page: https://ebrheum.com/ Substack: https://autoimmunedevreport.substack.com/
- Mar 5, 202613 min
E132: Romosozumab vs teriparatide for osteoproosis (STRUCTURE)
Quick podcast this week about a nifty head to head study that I had previously missed. Worth reading if - like me - you're still trying to figure out how the heck to manage osteoporosis. Paper: https://pubmed.ncbi.nlm.nih.gov/28755782/
- Jan 21, 202614 min
E131: A Sham-Controlled Sham of a Trial: RESET-RA
Today I cover the recent publication of the RESET-RA study, which evaluated vagal nerve stimulation to treat rheumatoid arthritis. Have a listen in full, but let me be clear upfront: I do not think this works and will not be referring any patients to receive it. This will forever be my pivotal example of the effect of unblinding, but would love to hear if you think different! Paper: https://www.nature.com/articles/s41591-025-04114-7 Supplement (see S4): https://www.nature.com/articles/s41591-025-04114-7#Sec27
- Dec 22, 202513 min
E130: Telitacicept for SLE
Surprisingly (unbelievably?) impressive RCT evaluating the Blys/APRIL inhibitor "telitacicept" for patients with SLE (mixed SLE and SLE-LN). Very curious to see where the FDA goes with this one. Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2414719
- Dec 4, 202515 min
E129: Long Term Routine Laboratory Monitoring in RA
Ever wonder how often you really need to check "monitoring" labs? If so then this is the podcast for you! Bryant England mentioned this during his excellent Year in Review session at ACR Convergence 2025. I've been meaning to cover it and finally got around to doing so. Have a listen and share with friends! Paper: https://pubmed.ncbi.nlm.nih.gov/40854212/
- Nov 12, 202519 min
E128: Nerandomilast for Autoimmune ILD (FIBRONEER-ILD)
Covering a very interesting study this week, which investiaged the PDE4B inhibitor nerandomilast for patients with progressive pulmonary fibrosis (specifically including 325 patients with autoimmune ILD). Would have been yet another ho hum trial if not for the big reveal... have a listen to find out! Article: https://www.nejm.org/doi/full/10.1056/NEJMoa2503643
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About The Evidence Based Rheumatology Podcast
A podcast for physicians about evidence based medicine in rheumatology. Each week we'll critique and apply a paper in the medical literature.
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